基本信息
浏览量:2
职业迁徙
个人简介
Our goal is to understand the molecular mechanisms that regulate blood-brain barrier (BBB) function during health and disease. The BBB is a specialized structure formed by the blood vessels in the central nervous system (CNS) that is critical for proper brain function as well as protecting the brain from injury and disease. In most tissues the blood vessels are leaky allowing a relatively free flow of molecules and ions from blood into tissues, whereas in the brain, the blood vessels tightly restrict the movement of molecules and ions between the blood and the brain. This barrier clamps the extracellular environment allowing for proper neuronal communication while also limiting toxins, pathogens and even the body’s own immune system from entering and damaging the CNS. Breakdown of the BBB occurs during stroke, edema, brain trauma, and multiple sclerosis and is a major component of the symptoms and progression of these diseases. Furthermore, the BBB not only impedes the movement of toxins and pathogens, but also inhibits the delivery of potential therapeutic agents to the CNS.
研究兴趣
论文共 84 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Eduardo Frias-Anaya,Helios Gallego-Gutierrez,Brendan Gongol,Shantel Weinsheimer,Catherine Chinhchu Lai,Marco Orecchioni,Aditya Sriram, Cassandra M Bui, Bliss Nelsen,Preston Hale,Angela Pham,Robert Shenkar,
biorxiv(2024)
Caterina P Profaci,Koji L Foreman, Lena Spieth,Vanessa Coelho-Santos, Stefan A Berghoff,Jackson T Fontaine, Danielle A Jeffrey,Sean P Palecek,Eric V Shusta, Gesine Saher,Andy Y Shih,Fabrice Dabertrand,
biorxiv(2024)
Caterina P Profaci, Sean S Harvey, Kaja Bajc, Tony Z Zhang, Alexander Z Zhang,Kelsey M Nemec,Gabriel L McKinsey, Aaron Longworth,Timothy P McMullen,Thomas D Arnold,Devon A Lawson, Frederick C Bennett,
biorxiv(2024)
crossref(2024)
Science advancesno. 5 (2024): eadi1737-eadi1737
Yinghua Ma, David Sannino,Jennifer R. Linden,Sylvia Haigh,Baohua Zhao, John B. Grigg,Paul Zumbo,Friederike Dündar,Daniel J. Butler,Caterina P. Profaci,Kiel M. Telesford,Paige N. Winokur,
Journal of Clinical Investigation (2023)
引用0浏览0引用
0
0
NATURE COMMUNICATIONSno. 1 (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn