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个人简介
I am interested in the pathogenesis of chronic airways diseases of childhood. My work includes basic and clinical research. In the area of basic research, my laboratory has focused on immunoregulation of inflammation in cystic fibrosis, finding deficiencies of activated T cells from CF patients in production of counter-regulatory cytokines (IL-10, IFN-gamma) and redox metabolism. In the arena of clinical research, as a member of the CFF Therapeutics Development Network our research group conducts many trials. I have particular interests in the areas of aerosol therapy with drugs, biologics and gene vectors; mechanisms of pulmonary inflammation and immunomodulatory therapy; and corrrection of CFTR-dependent cell biology defects. We are also investigating new treatments for CF complications such as diabetes and osteoporosis, internet-based disease management, and trials of asthma drugs. Recent projects focus on development of biomarkers and treatments for allergic fungal lung disease, e.g. inhaled antifungals.
研究兴趣
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Joseph E Levitt,Haley Hedlin,Sophie Duong,Di Lu,Justin Lee,Bryan Bunning, Nadia Elkarra,Benjamin A Pinsky, Eileen Heffernan,Eric Springman,Richard B Moss,Hector F Bonilla,
J. E. Levitt,H. Hedlin,S. Duong, D. Lu,J. Lee, N. Elkarra,B. Pinsky, E. Heffernan, E. Springman, H. Bonilla,J. Parsonnet, R. T. Zamanian,
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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