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Focus of our research has been given to the aberrant immune response underlying various rheumatic disease.
Break of immunological tolerance is at the basis of the development of autoimmunity and consequently autoimmune diseases. We aim to understand how B-cell tolerance towards self-antigens in rheumatic disease is broken. Emphasis is given to B-cells and auto-antibodies recognizing post-translationally modified protein-antigens in rheumatoid arthritis. However, also other B-cell- and auto-antibody responses present in other rheumatic diseases are studied. We thrive to implement the knowledge acquired on the breach of tolerance and the evolution of human auto-reactive antibody- and B-cell responses into the design of preventive strategies and/or interventions aiming to restore normal immune-homeostasis against autoantigens and cure of B-cell mediated auto-immune diseases. The ultimate goal of our studies is to understand how rheumatic disorders arise and are maintained with the aim to treat patients in an earlier phase to cure or even prevent disease.
Break of immunological tolerance is at the basis of the development of autoimmunity and consequently autoimmune diseases. We aim to understand how B-cell tolerance towards self-antigens in rheumatic disease is broken. Emphasis is given to B-cells and auto-antibodies recognizing post-translationally modified protein-antigens in rheumatoid arthritis. However, also other B-cell- and auto-antibody responses present in other rheumatic diseases are studied. We thrive to implement the knowledge acquired on the breach of tolerance and the evolution of human auto-reactive antibody- and B-cell responses into the design of preventive strategies and/or interventions aiming to restore normal immune-homeostasis against autoantigens and cure of B-cell mediated auto-immune diseases. The ultimate goal of our studies is to understand how rheumatic disorders arise and are maintained with the aim to treat patients in an earlier phase to cure or even prevent disease.
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Nature Communicationsno. 1 (2024): 1-13
ANNALS OF THE RHEUMATIC DISEASES (2024)
ANNALS OF THE RHEUMATIC DISEASESno. 2 (2024): 267-270
Catherine D. Hughes,Sarah E. Ryan,Kathryn J. A. Steel, Michelle D. van den Beukel,L. A. Trouw,Karin A. J. van Schie,Rene E. M. Toes,Bina Menon,Bruce W. Kirkham,Leonie S. Taams
RMD Openno. 4 (2023)
Jana Koers,Rocco Sciarrillo,Ninotska I.L. Derksen,Esther M. Vletter,Yvonne E. Fillié-Grijpma, Elisabeth Raveling-Eelsing, Nuno A.G. Graça, Thiemo Leijser,Hendri H. Pas, L. Laura van Nijen-Vos,Maaike V.J. Braham, Anne-Marie Buisman,
Journal of Allergy and Clinical Immunologyno. 6 (2023): 1646-1654
RMD OPENno. 3 (2023)
NATURE COMMUNICATIONSno. 1 (2023)
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Journal of immunology (Baltimore, Md. : 1950)no. 2 (2023): 158-167
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