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Ras- and Rho-related proteins are small GTPases activated downstream of multiple receptors that control many cellular processes including cell cycle progression, apoptosis, cell motility, and cellular differentiation. Since they promote transformation and tumor metastasis, they represent important targets for cancer therapy. We have investigated the effects of prenylation inhibitors (agents that inhibit important post-translational modifications of Ras and Rho) on signaling in solid tumors and leukemic cells. Through a proteomics approach, we have identified novel Rho effector proteins, and defined their functions in cancer cells. We are also interested in the cross-talk between Ras and Rho and other signaling pathways, and are examining mechanisms whereby cAMP- and cGMP-dependent protein kinases regulate the activities of these proteins.
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Science signalingno. 821 (2024): eadi7861-eadi7861
JACC-BASIC TO TRANSLATIONAL SCIENCEno. 1 (2024): 46-62
Hema Kalyanaraman,Darren E. Casteel, Justin A. Cabriales,John Tat,Shunhui Zhuang,Adriano Chan, Kenneth L. Dretchen,Gerry R. Boss,Renate B. Pilz
JACC: Basic to Translational Scienceno. 1 (2024): 46-62
JOURNAL OF TRANSLATIONAL MEDICINEno. SUPPL 1 (2023)
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The Journal of biological chemistryno. 4 (2023): 104584-104584
Hema Kalyanaraman,Shyamsundar Pal China, Justin A Cabriales, Jafar Moininazeri,Darren E Casteel,Julian J Garcia,Van W Wong,Albert Chen,Robert L Sah,Gerry R Boss,Renate B Pilz
JOURNAL OF BIOLOGICAL CHEMISTRYno. 8 (2022)
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PNAS Nexus (2022)
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