I use large scale genome-wide association and sequencing studies to identify genes that affect an individual's risk of developing late-onset Alzheimer’s disease.
I am a neurogeneticist with over ten years experience in neurodegeneration research. I have a particular interest in the generation of large-scale powerful datasets and data analysis. I have significant experience of International collaboration, maintaining networks and producing high quality publications. My recent work has included leading genome-wide association projects, such as exome chip array studies. My current work focuses on the translation of genetic findings to disease relevant induced pluripotent cell models, and utilizes Next Generation Sequencing (NGS) technology to identify novel risk loci for early-onset Alzheimer’s disease.
My research identifies susceptibility genes for Alzheimer's disease. I have a particular interest in analysing rare frequency genetic variation and my recent work implicates immune cells, specifically microglia in disease development.