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职业迁徙
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Cytotoxic cells, including natural killer (NK) cells and cytotoxic T cells, recognize and kill infected and transformed cells. Our laboratory investigates mechanisms of recognition of cancer cells and infected cells by natural killer cells and T cells. Furthermore we investigate mechanisms by which tumors and infectious agents naturally activate or inhibit productive responses by cytotoxic cells, or desensitize the cells by inducing anergy. Our aim is to harness these findings to improve existing immunotherapies for cancer and design new ones. We have employed our understanding of NK recognition, activation and inhibition to establish therapy combinations that super-activate NK cells, while at the same time preventing desensitization and inhibition of the cells. These combinations show promise as new therapies for cancers that are refractory to existing immunotherapies.
Cytotoxic cells, including natural killer (NK) cells and cytotoxic T cells, recognize and kill infected and transformed cells. Our laboratory investigates mechanisms of recognition of cancer cells and infected cells by natural killer cells and T cells. Furthermore we investigate mechanisms by which tumors and infectious agents naturally activate or inhibit productive responses by cytotoxic cells, or desensitize the cells by inducing anergy. Our aim is to harness these findings to improve existing immunotherapies for cancer and design new ones. We have employed our understanding of NK recognition, activation and inhibition to establish therapy combinations that super-activate NK cells, while at the same time preventing desensitization and inhibition of the cells. These combinations show promise as new therapies for cancers that are refractory to existing immunotherapies.
研究兴趣
论文共 142 篇作者统计合作学者相似作者
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Rutger D. Luteijn, Sypke R. van Terwisga, Jill E. Ver Eecke, Liberty Onia,Shivam A. Zaver,Joshua J Woodward,David H. Raulet,Frank J.M. van Kuppeveld
biorxiv(2022)
Natalie Wolf,Cristina Blaj,Lora Picton,Gail Snyder,Li Zhang, J. Christopher, Nicolai,Chudi O. Ndubaku,Sarah M. McWhirter,K. Christopher Garcia,David H. Raulet
semanticscholar(2021)
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Christopher J Nicolai,Natalie Wolf, I-Chang Chang, Georgia Kirn,Assaf Marcus,Chudi O Ndubaku,Sarah M McWhirter,David H Raulet
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