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Dr. Ten Haken has enjoyed a rich and varied career in applications of physics to radiation oncology. These range from early-career measurements of tissue perfusion via photon activation, followed by studies of therapeutic neutron beam dosimetry, on through additional investigations into photon and electron beam dosimetry followed by early innovations in 3-D treatment planning and up to mid-career assessments (together with direction of graduate students and post-docs) of the impact of geometric uncertainties and organ motion on radiation therapy treatments.
These later studies helped alert the community to the need to incorporate patient specific anatomy and setup uncertainties and organ motion into the treatment planning process. Most gratifying to himwas the development of a phase I dose escalation methodology for conformal radiation therapy treatments. Such strategies did not exist prior to the UM team's efforts, and a one-size-fits-all approach to radiation treatments was the standard (i.e., a single tumor dose regardless of tumor size, or more importantly normal tissue dose distributions).
Dr. Ten Haken was the primary innovator of an iso-toxicity dose escalation scheme that led to clinical trials that demonstrated the ability to safely deliver higher doses of radiation to tumors in the liver and lung than had previously been thought possible. Analyses of the results of those dose escalation studies led to the parameterization of normal tissue complication probability (NTCP) models for use in subsequent clinical trials. These published results were among the first of their kind. This led naturally to the desire to use these mathematical models of predicted outcomes directly in optimization of treatment plans. A series of papers demonstrated the strength and flexibility of these approaches. More recently, Dr. Ten Haken has collaborated with others toward the use of physiological imaging and other biomarkers into treatment response assessment of both tumors and normal tissues to irradiation, with the goal of incorporating these techniques into individualized response-based adaptive therapy regimens.
These later studies helped alert the community to the need to incorporate patient specific anatomy and setup uncertainties and organ motion into the treatment planning process. Most gratifying to himwas the development of a phase I dose escalation methodology for conformal radiation therapy treatments. Such strategies did not exist prior to the UM team's efforts, and a one-size-fits-all approach to radiation treatments was the standard (i.e., a single tumor dose regardless of tumor size, or more importantly normal tissue dose distributions).
Dr. Ten Haken was the primary innovator of an iso-toxicity dose escalation scheme that led to clinical trials that demonstrated the ability to safely deliver higher doses of radiation to tumors in the liver and lung than had previously been thought possible. Analyses of the results of those dose escalation studies led to the parameterization of normal tissue complication probability (NTCP) models for use in subsequent clinical trials. These published results were among the first of their kind. This led naturally to the desire to use these mathematical models of predicted outcomes directly in optimization of treatment plans. A series of papers demonstrated the strength and flexibility of these approaches. More recently, Dr. Ten Haken has collaborated with others toward the use of physiological imaging and other biomarkers into treatment response assessment of both tumors and normal tissues to irradiation, with the goal of incorporating these techniques into individualized response-based adaptive therapy regimens.
研究兴趣
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Scientific Reportsno. 1 (2023): 1-14
International journal of radiation oncology, biology, physicsno. 5 (2023): 1236-1240
Practical radiation oncologyno. 6 (2023): e504-e514
Medical physicsno. 9 (2023): 5597-5608
Cancer journal (Sudbury, Mass.)no. 4 (2023): 238-242
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Daniel R Owen,Yilun Sun, Jim C Irrer,Matthew J Schipper,Caitlin A Schonewolf,Stefanie Galbán,Shruti Jolly,Randall K Ten Haken, C J Galbán,M M Matuszak
Advances in radiation oncologyno. 4 (2022): 100980-100980
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