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The mammalian olfactory system provides an excellent model to study two of the important questions in molecular neurobiology. The continual replacement of olfactory receptor neurons mimics many aspects of neuronal differentiation and development in the brain. The olfactory system, therefore, provides a unique opportunity to observe processes in adults that, in other neuronal systems, only occur in the embryo. Additionally, the mammalian olfactory system has the remarkable ability to detect a wide variety of odorant molecules with high sensitivity and specificity. Olfactory acuity likely results from the contributions at the levels of anatomy, cellular structure and organization, biochemistry, genetics and neuronal connectivity. My laboratory uses biochemical and molecular genetic techniques to examine the mechanisms underlying development in the olfactory system, as well as the processes responsible for odorant detection.
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Cell stem cellno. 4 (2019): 501-513.e5
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