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Diaz-Arrastia has authored numerous publications, including, articles in peer-reviewed journals and is most known for his research in internal medicine, specifically for his contributions towards advancing contemporary understanding of traumatic brain injury. His research work spans the fields of neurodegeneration, traumatic brain injury, and post-traumatic epilepsy.
Traumatic brain injury
Diaz-Arrastia's early research work focuses on the role of traumatic cerebral vascular injury (TCVI) in the development of functional deficits and chronic disability following traumatic brain injury, concluding that TCVI is a frequent occurrence and endorsed the use of non-invasive imaging techniques such as MRI-ASL, TCD, and NIRS to assess microvascular function post-traumatic brain injury. His group was the first group to show that phosphodiesterase 5 (PDE5) inhibition reverses part of the deficit in cerebrovascular reactivity after TBI, and constitutes a promising therapy for traumatic cerebrovascular injury.
Diaz-Arrastia's group was among the first to use diffusion tensor imaging (DTI) MRI to study traumatic axonal injury during the acute, subacute, and chronic period after traumatic brain injury. In a series of publications, they showed that DTI measures of fractional anisotropy (FA) and mean diffusivity (MD) are altered in patients with TBI within 24 hours of injury, and change dynamically over the subsequent weeks. Their group was also the first to use functional MRI (resting state functional connectivity) to identify functional disruption of white matter tracts in the acute and chronic stage after TBI.
Post traumatic epilepsy
Diaz-Arrastia's research on post-traumatic epilepsy explores the prevalence, risk factors, clinical features, and management options of epilepsy that arise as a result of a traumatic brain injury. His research on surgical outcomes in Post-Traumatic Epilepsy revealed that surgery could be a viable option for reducing seizure frequency or severity, even in cases where other treatments have been unsuccessful. His work has focused on establishing the electrophysiologic and neuroimaging endophenotypes of TBI. His group showed that mesial temporal sclerosis was a common finding in post-traumatic epilepsy of adult onset.He published a study of post-traumatic epilepsy evaluated with MRI and video-EEG monitoring over 10 years at a single epilepsy center.
Biomarkers for traumatic brain injury
In his exploration of new ways to diagnose mild traumatic brain injuries by testing for certain proteins in both the blood and small particles released by brain cells, also known as extracellular vesicles, his work revealed that these two sources of protein information i.e. (plasma and brain-derived extracellular vesicles) provide independent diagnostic information and when combined, accurately diagnose mild traumatic brain injuries. Evaluating the effects of time and age on traumatic brain injury, he demonstrated that glial fibrillary acidic protein has good to excellent performance in discriminating TBI from other diagnostic groups across all age categories up to at least 3 days post-injury and suggested that the addition of a blood-based diagnostic to the evaluation of traumatic brain injury has the potential to improve diagnosis.
Traumatic brain injury
Diaz-Arrastia's early research work focuses on the role of traumatic cerebral vascular injury (TCVI) in the development of functional deficits and chronic disability following traumatic brain injury, concluding that TCVI is a frequent occurrence and endorsed the use of non-invasive imaging techniques such as MRI-ASL, TCD, and NIRS to assess microvascular function post-traumatic brain injury. His group was the first group to show that phosphodiesterase 5 (PDE5) inhibition reverses part of the deficit in cerebrovascular reactivity after TBI, and constitutes a promising therapy for traumatic cerebrovascular injury.
Diaz-Arrastia's group was among the first to use diffusion tensor imaging (DTI) MRI to study traumatic axonal injury during the acute, subacute, and chronic period after traumatic brain injury. In a series of publications, they showed that DTI measures of fractional anisotropy (FA) and mean diffusivity (MD) are altered in patients with TBI within 24 hours of injury, and change dynamically over the subsequent weeks. Their group was also the first to use functional MRI (resting state functional connectivity) to identify functional disruption of white matter tracts in the acute and chronic stage after TBI.
Post traumatic epilepsy
Diaz-Arrastia's research on post-traumatic epilepsy explores the prevalence, risk factors, clinical features, and management options of epilepsy that arise as a result of a traumatic brain injury. His research on surgical outcomes in Post-Traumatic Epilepsy revealed that surgery could be a viable option for reducing seizure frequency or severity, even in cases where other treatments have been unsuccessful. His work has focused on establishing the electrophysiologic and neuroimaging endophenotypes of TBI. His group showed that mesial temporal sclerosis was a common finding in post-traumatic epilepsy of adult onset.He published a study of post-traumatic epilepsy evaluated with MRI and video-EEG monitoring over 10 years at a single epilepsy center.
Biomarkers for traumatic brain injury
In his exploration of new ways to diagnose mild traumatic brain injuries by testing for certain proteins in both the blood and small particles released by brain cells, also known as extracellular vesicles, his work revealed that these two sources of protein information i.e. (plasma and brain-derived extracellular vesicles) provide independent diagnostic information and when combined, accurately diagnose mild traumatic brain injuries. Evaluating the effects of time and age on traumatic brain injury, he demonstrated that glial fibrillary acidic protein has good to excellent performance in discriminating TBI from other diagnostic groups across all age categories up to at least 3 days post-injury and suggested that the addition of a blood-based diagnostic to the evaluation of traumatic brain injury has the potential to improve diagnosis.
研究兴趣
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Nature reviews. Neurologypp.1-15, (2024)
Research square (2024)
John Arena,Douglas Smith,Ramon Diaz-Arrastia,D. Kacy Cullen, Rui Xiao, Danielle Harris,Cillian Lynch,Victoria Johnson
Neurosurgeryno. Supplement_1 (2024): 71-71
Journal of neurotrauma (2024)
John K Yue,Esther Lim Yuh, Mahmoud M Elguindy,Xiaoying Sun, Thomas Arjan Van Essen,Hansen Deng,Patrick J Belton, Gabriela G Satris,Justin C Wong,Alex Valadka, Frederick Kofi Korley,Claudia S Robertson,
Journal of neurotrauma (2024)
James J. Gugger,Alexa E. Walter,Ramon Diaz-Arrastia,Juebin Huang, Clifford R. Jack,Robert Reid, Anna M. Kucharska-Newton,Rebecca F. Gottesman,Andrea L. C. Schneider,Emily L. Johnson
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGYno. 2 (2024): 342-354
Neurologyno. 8 (2024): e209269-e209269
Matthew P Kirschen,Minhui Ouyang, Bhavesh Patel, Jeffrey I Berman,Ryan Burnett,Robert A Berg,Ramon Diaz-Arrastia,Alexis Topjian,Hao Huang,Arastoo Vossough
Resuscitation (2024): 110128-110128
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