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Our research focuses on dynamics and mechanism of complex biological processes such as: 1) protein folding, 2) protein misfolding and amyloidosis, 3) enzyme functional dynamics, 4) GPCR functional dynamics, and 5) Direct molecular imaging of proteins and nanoparticles by MRI. In many cases, we make use of 19F or 13C,1H NMR to detect subtle low-lying states within an ensemble, and piece together a mechanistic description. 19F NMR chemical shifts are exquisitely sensitive to molecular environments. Thus, subtle differences in conformation, folding intermediates, or different aggregation states are more likely to be resolved by 19F NMR than by other methods.
Our research focuses on dynamics and mechanism of complex biological processes such as: 1) protein folding, 2) protein misfolding and amyloidosis, 3) enzyme functional dynamics, 4) GPCR functional dynamics, and 5) Direct molecular imaging of proteins and nanoparticles by MRI. In many cases, we make use of 19F or 13C,1H NMR to detect subtle low-lying states within an ensemble, and piece together a mechanistic description. 19F NMR chemical shifts are exquisitely sensitive to molecular environments. Thus, subtle differences in conformation, folding intermediates, or different aggregation states are more likely to be resolved by 19F NMR than by other methods.
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CANADIAN JOURNAL OF CHEMISTRY (2023)
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Shuya Kate Huang,Louis-Philippe Picard, Rima S. M. Rahmatullah,Aditya Pandey,Ned Van Eps,Roger K. Sunahara,Oliver P. Ernst,Adnan Sljoka,R. Scott Prosser
Nature Structural & Molecular Biologyno. 4 (2023): 502-511
R S Prosser, Nicholas A Alonzi
Current opinion in pharmacology (2023): 102377-102377
BIOCHEMISTRYno. 22 (2023): 3265-3275
BIO-PROTOCOL (2022)
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Robert Prosser, Shuya Huang, Rima Rahmatullah,Aditya Pandey,Ned Van Eps,Roger Sunahara,Oliver Ernst,Adnan Sljoka
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