基本信息
浏览量:567
职业迁徙
个人简介
Dr. Herbst’s primary mission is the enhanced integration of clinical, laboratory, and research programs to bring new treatments to cancer patients. He has led the Phase I development of several of the new generation of targeted agents for non-small cell lung cancer (NSCLC), including gefitinib, erlotinib, cetuximab, and bevacizumab. More recently, he participated in the successful registration of pembrolizumab for the treatment of advanced non-small cell lung cancer, following the successful Yale-led KEYNOTE 10 study of the immune therapy drug commonly used to treat other cancers. He was co-leader for the BATTLE-1 clinical trial program, co-leads the subsequent BATTLE-2 clinical trial program, and served as a Co-program Leader of the Developmental Therapeutics Program for the YCC Support Grant. Dr. Herbst’s laboratory work is focused on immunotherapy angiogenesis; dual epidermal growth factor receptor (EGFR)/vascular endothelial growth factor receptor (VEGFR) inhibition in NSCLC, and targeting KRAS-activated pathways. More recently, he has explored predictive biomarkers for the use of immunotherapy agents. This work has been translated from the preclinical to clinical setting in multiple Phase II and III studies which he has led.
研究兴趣
论文共 604 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Targeted Oncologyno. 2 (2024): 1-4
Douglas I. Lin,Richard S. P. Huang, Ioannis Ladas,Rachel B. Keller,Nimesh R. Patel, Sotirios Lakis,Brennan Decker,Tyler Janovitz,Douglas A. Mata, Jeffrey S. Ross,Jo-Anne Vergilio,Julia A. Elvin,
FRONTIERS IN ONCOLOGY (2024): 1328512-1328512
Joel W Neal, Katherine Minichiello, Ryan Brennick,Richard S P Huang,Matthew C Hiemenz, Cornel Amler,Jyoti Patel,Roy Herbst,Karen L Reckamp,Hossein Borghaei, Louise Highleyman,Mary W Redman,
The oncologist (2024)
H. Borghaei,F. de Marinis, D. Dumoulin, C. Reynolds, W. S. M. E. Theelen, I. Percent,V. Gutierrez Calderon,M. L. Johnson, A. Madroszyk-Flandin, E. B. Garon, K. He, D. Planchard,
ANNALS OF ONCOLOGYno. 1 (2024): 66-76
Clinical cancer research : an official journal of the American Association for Cancer Researchno. 1 (2024): 29-32
Nature medicineno. 7 (2023): 1718-1727
引用0浏览0WOSNATURE引用
0
0
Robert Johnston,Hartmut Koeppen,Roy S Herbst,Kurt Schalper,Filippo De Marinis,Giuseppe Giaccone,Jacek Jassem,Marcus Ballinger, Barani Kumar Rajendran,David R Spigel,Miguel López de Rodas,Minu K Srivastava,
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
引用0浏览0引用
0
0
Journal of Thoracic Oncology (2023)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn