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个人简介
Our research is centered on the innate host response to microbial colonization and infection. We are keenly interested in the inflammatory component of the innate host response. Our laboratory studies both the microbial components that elicit inflammation and the activation pathways employed by the host in response to different microbial components. We study responses to both commensal and pathogenic bacteria. We employ biochemical isolation and analytical techniques to characterize the microbial components. Examples of microbial components that we have studied are lipopolysaccharide form gram negative bacteria and lipoteichoic acid from gram positive bacteria. We use a variety of different in vitro cell culture systems to analyze host responses. Examples of systems that have used are human and mouse endothelial cells, human epithelial cells, human and mouse monocytes. We also construct cell lines (both stable and transient) to examine select components of the host innate response system.
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论文共 123 篇作者统计合作学者相似作者
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JOURNAL OF PERIODONTOLOGY (2023)
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Journal of periodontology (2023)
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Journal of Periodontology (2023)
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Proceedings of the National Academy of Sciences of the United States of Americano. 41 (2023)
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Frontiers in oral health (2022): 911420
PERIODONTOLOGY 2000no. 1 (2021): 8-13
Frontiers in oral health (2021): 689475-689475
Scientific Reportsno. 1 (2021): 1-3
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