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Protein misfolding and human disease
Conversion of genetic information into functional protein products requires the proper folding of polypeptide chains in the crowded intracellular environment. Disruption of these folding pathways through exposure to either environmental or genetic factors is associated with numerous human diseases – collectively referred to as protein misfolding diseases. Using proteomic, biophysical and cell biological approaches, work in the Wiseman lab is directed towards understanding the physical, chemical and biological factors that dictate intracellular protein folding as it relates to human disease. Currently, we have three ongoing projects focused on protein folding in vivo: 1) development of novel biosensors that report on protein folding in the complex intracellular environment; 2) characterization of mitochondrial folding efficiency in the context of neurodegenerative disease; and 3) elucidation of the impact of intracellular signaling pathways on protein folding and trafficking in the early secretory pathway.
Protein misfolding and human disease
Conversion of genetic information into functional protein products requires the proper folding of polypeptide chains in the crowded intracellular environment. Disruption of these folding pathways through exposure to either environmental or genetic factors is associated with numerous human diseases – collectively referred to as protein misfolding diseases. Using proteomic, biophysical and cell biological approaches, work in the Wiseman lab is directed towards understanding the physical, chemical and biological factors that dictate intracellular protein folding as it relates to human disease. Currently, we have three ongoing projects focused on protein folding in vivo: 1) development of novel biosensors that report on protein folding in the complex intracellular environment; 2) characterization of mitochondrial folding efficiency in the context of neurodegenerative disease; and 3) elucidation of the impact of intracellular signaling pathways on protein folding and trafficking in the early secretory pathway.
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论文共 150 篇作者统计合作学者相似作者
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Molecular biology of the cellno. 5 (2024): ar74-ar74
Christoph Hofmann, Marjan Aghajani, Cecily D. Alcock,Erik A. Blackwood,Clara Sandmann,Nicole Herzog,Julia Groß,Lars Plate,R. Luke Wiseman,Randal J. Kaufman,Hugo A. Katus,Tobias Jakobi,
Journal of Molecular and Cellular Cardiology (2024): 12-24
Caroline Stanton, Chavin Buasakdi, Jie Sun, Ian Levitan, Prerona Bora,Sergei Kutseikin,Luke Wiseman,Michael Bollong
crossref(2024)
Thierry Touvier,Francesca A Veneri,Anke Claessens,Cinzia Ferri,Rosa Mastrangelo, Noémie Sorgiati,Francesca Bianchi, Serena Valenzano,Ubaldo Del Carro,Cristina Rivellini,Phu Duong, Michael E Shy,
bioRxiv : the preprint server for biology (2024)
Caroline Stanton, Jie Sun,Kayla Nutsch,Jessica D. Rosarda,Thu Nguyen, Chloris Li-Ma, Evert Njomen,Bruno Melillo,Sergei Kutseikin,Enrique Saez,Benjamin F. Cravatt,John R. Teijaro,
Valerie Perea, Christian Cole,Justine Lebeau, Vivian Dolina,Kelsey R Baron,Aparajita Madhavan,Jeffery W. Kelly,Danielle Ann Grotjahn,Rockland Luke Wiseman
crossref(2023)
Jeyun Jo,Jisu Kim,Lara Ibrahim, Manoj Kumar, Jonathan Iaconelli,Cong So Tran,Hyung Ryong Moon, Yunjin Jung,R. Luke Wiseman, Luke L. Lairson,Arnab K. Chatterjee,Michael J. Bollong,
ISRAEL JOURNAL OF CHEMISTRY (2023)
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