基本信息
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职业迁徙
个人简介
Research focus:
HAB/LAB mice as an animal model to simulate anxiety disorders and comorbid depression
Extinction of learned fear and acoustic startle response
Social discrimination test
Neuropeptide S effects
Combined expression and genotypic approaches to identify candidate genes and biomarkers of trait anxiety
Causal associations: F2 panel and clinical samples
Interaction between environmental epigenomics and genetic predisposition in shaping the anxiety phenotype of HAB vs. LAB mice
Biomarker identification in HAB mice
Biomarker Identification in a Mouse Model for Trait Anxiety
Functional Manganese-enhanced MRI
Towards in vivo functions of Urocortin 2 and Urocortin 3 using loss- and gain-of-function mouse models
Translocator protein (18 kDa) as a target for anxiolytics without benzodiazepine inherent side effects
High-speed imaging of neuronal network activity in brain regions relevant for depression and anxiety
Electrophysiological correlates of anxiety- and depression-like behaviors
Comparison of sleep architectures in mouse models of anxiety/depression and chronic stress
Selected publications:
Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S, Specht M, Kohli MA, Kloiber S, Ising M, Heck A, Pfister H, Zimmermann P, Lieb R, Pütz B, Uhr M, Weber P, Deussing JM, Gonic M, Bunck M, Keßler MS, Frank E, Hohoff C, Domschke K, Krakowitzky P, Maier W, Bandelow B, Jacob C, Deckert J, Schreiber S, Strohmaier J, Nöthen M, Cichon S, Rietschel M, Bettecken T, Keck ME, Landgraf R, Müller-Myhsok B, Holsboer F and Binder EB. (2011) TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Mol. Psychiatry 16: 647-663.
Fenzl T, Touma C, Romanowski CP, Ruschel J, Holsboer F, Landgraf R, Kimura M and Yassouridis A. (2011) Sleep disturbances in highly stress reactive mice: Modeling endophenotypes of major depression. BMC Neurosci. 12, 29.
Gaburro S, Stiedl O, Giusti P, Sartori SB, Landgraf R and Singewald N. (2011) A mouse model of high trait anxiety shows reduced heart-rate variability that can be reversed by anxiolytic drug treatment. Int. J. Neuropsychopharmacol. 15: 1-15.
Kessler MS, Bosch OJ, Bunck M, Landgraf R and Neumann ID (2011). Maternal care differs in mice bred for high versus low trait anxiety: impact of brain vasopressin and cross-fostering. Soc. Neurosci. 6: 156-168.
Tasan RO, Bukovac A, Peterschmitt YN, Sartori SB, Landgraf R, Singewald N and Sperk G. (2011) Altered GABA transmission in a mouse model of increased trait anxiety. Neuroscience 183: 71-80.
研究兴趣
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Roshan R Naik,Sergey V Sotnikov,Rebekka P Diepold,Stella Iurato, Patrick O Markt,Andrea Bultmann, Nadine Brehm,Tobias Mattheus,Beat Lutz,Angelika Erhardt,Elisabeth B Binder,Ulrike Schmidt,
Model Animals in Neuroendocrinologypp.257-278, (2018)
mag(2015)
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