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His laboratory has a major focus on investigating the role of the fibrinolytic system in the central nervous system. He has a particular interest in understanding how the fibrinolytic protease, tissue type plasminogen activator (t-PA) potentiates neuronal injury and modulates blood brain barrier permeability and the relationship of this on the use of t-PA and related thrombolytic agents in ischaemic stroke. His laboratory is also exploring the influence of the fibrinolytic system in traumatic brain injury and in models of neurodegeneration. Other interests include the mechanism by which t-PA functions enzymatically in the brain. He is also interested in exploring the role of platelet derived products on neuronal function, how clot formation in the brain may modulate brain function in addition to causing ischaemia and a new project exploring the role of plasminogen activation in multiple sclerosis.
研究兴趣
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Natalie Trinh, Kaustubh R. Bhuskute, Nikhil R. Varghese, Jessica A. Buchanan, Yijia Xu,Fiona M. Mccutcheon,Robert L. Medcalf,Katrina A. Jolliffe,Margaret Sunde,Elizabeth J. New,Amandeep Kaur
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INTERNATIONAL JOURNAL OF STROKEno. 2 (2023): 23-23
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The New England journal of medicineno. 2 (2023): 127-136
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Research and Practice in Thrombosis and Haemostasis (2023): 100398-100398
Frontiers in Immunology (2023): 1303385
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Research and practice in thrombosis and haemostasisno. 6 (2023): 102166-102166
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