R. Ian Storer - Discovery Sci, BioPharmaceutial R&D, AstraZeneca

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Development of Compounds for Targeted Degradation of Mammalian Cryptochrome Proteins

Jack Munns,Andrew D. Beale,Iacovos N. Michaelides,Sew Y. Peak-Chew,Andrei Mihut, Christine T. Major-Styles,Aiwei Zeng,R. Ian Storer,Rachel S. Edgar,Kevin Moreau,John S. O'Neill

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCESno. 1918 (2025)

引用2浏览0WOS引用

Fragment-Based Discovery of Novel MUS81 Inhibitors

Gavin W. Collie,Ulf Borjesson,Yunhua Chen, Zhiqiang Dong,Paolo Di Fruscia,Andrea Gohlke, Anna Hoyle,Thomas A. Hunt,Mehul H. Jesani, Haiou Luo,Jakub Luptak,Alexander G. Milbradt,Priyanka Narasimhan,Martin Packer,Saleha Patel, Jingchuan Qiao,R. Ian Storer,Christopher J. Stubbs,Jonathan Tart,Caroline Truman,Anderson T. Wang, Matthew G. Wheeler,Jon Winter-Holt

ACS MEDICINAL CHEMISTRY LETTERSno. 7 (2024): 1151-1158

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Hit Me with Your Best Shot: Integrated Hit Discovery for the Next Generation of Drug Targets

S. Neha Ashraf,J. Henry Blackwell,Geoffrey A. Holdgate,Simon C. C. Lucas, Alisa Solovyeva,R. Ian Storer,Benjamin C. Whitehurst

Drug discovery today（2024）

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Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders

Simon C. C. Lucas, Afshan Ahmed, S. Neha Ashraf,Argyrides Argyrou,Matthias R. Bauer,Gian Marco De Donatis,Sylvain Demanze, Frederik Eisele,Lucia Fusani,Andreas Hock,Ganesh Kadamur, Shuyou Li, Abigail Macmillan-Jones,Iacovos N. Michaelides,Christopher Phillips, Marie Rehnstrom, Magdalena Richter,Monica C. Rodrigo-Brenni,Fiona Shilliday, Peng Wang,R. Ian Storer

Journal of Medicinal Chemistryno. 7 (2024): 5538-5566

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Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors

Simon C. C. Lucas,J. Henry Blackwell,Ulf Borjesson,David Hargreaves,Alexander G. Milbradt,Mark J. Bostock, Samiyah Ahmed,Kevin Beaumont,Tony Cheung,Sylvain Demanze,Andrea Gohlke,Carine Guerot,Afreen Haider,Vasudev Kantae,Gregory W. Kauffman,Olaf Kinzel, Lea Kupcova,Michael D. Lainchbury,Michelle L. Lamb, Leonardo Leon, Adeline Palisse, Claudia Sacchetto,R. Ian Storer,Nancy Su, Clare Thomson, John Vales,Yunhua Chen, Xiaolong Hu

JOURNAL OF MEDICINAL CHEMISTRYno. 18 (2024): 16455-16479

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Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery

Benjamin C. Whitehurst,Matthias R. Bauer,Fredrik Edfeldt,Anders Gunnarsson,Christian Margreitter,Philip B. Rawlins,R. Ian Storer

Journal of Medicinal Chemistry（2023）

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Discovery and Optimization of the First ATP Competitive Type-III C-Met Inhibitor

JOURNAL OF MEDICINAL CHEMISTRYno. 13 (2023): 8782-8807

引用4浏览0WOS引用

Rapid PROTAC Discovery Platform: Nanomole-Scale Array Synthesis and Direct Screening of Reaction Mixtures

Mateusz P. Plesniak, Emilia K. Taylor, Frederik Eisele, Christopher M. B. K. Kourra,Iacovos N. Michaelides, Alice Oram,Johan Wernevik,Zulma Santisteban Valencia, Hannah Rowbottom, Nadia Mann,Linda Fredlund, Valentyna Pivnytska,Anna Noven, Mohammad Pirmoradian,Thomas Lundback,R. Ian Storer,Mariell Pettersson, Gian M. De Donatis, Marie Rehnstrom

ACS MEDICINAL CHEMISTRY LETTERSno. 12 (2023): 1882-1890

引用9浏览0WOS引用

Fragment Screening at AstraZeneca: Developing the Next Generation Biophysics Fragment Set

Simon C. C. Lucas,Ulf Borjesson,Mark J. Bostock, John Cuff,Fredrik Edfeldt,Kevin J. Embrey,Per-Olof Eriksson,Andrea Gohlke, Anders Gunnarson,Michael Lainchbury,Alexander G. Milbradt,Rachel Moore,Philip B. Rawlins,Ian Sinclair, Christopher Stubbs,R. Ian Storer

RSC Medicinal Chemistry（2022）

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