Dr. Frye is a clinical pharmacologist by training and a licensed pharmacist. His search focuses on identifying factors that contribute to variability in drug response. In particular he has focused on drug metabolizing enzymes that contribute to pharmacokinetic variability observed with many drugs and natural products. Dr. Frye’s work in this area is currently supported by NCCAM, NIDCR and NIGMS. He serves on the editorial boards of Pharmacotherapy, The Open Drug Metabolism Journal, and Annals of Pharmacotherapy and as an ad-hoc reviewer for many journals, including Drug Metabolism and Dispostion and Clinical Pharmacology and Therapeutics.