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Description of Research Expertise
My laboratory studies the proteins that control the actin cytoskeleton and cytoskeleton-membrane connections, as well as the signaling cascades that regulate their activities. We use a broad spectrum of experimental approaches, spanning structural biology, biochemistry and cell biology, allowing us to correlate structure to function.
Cytoskeletal proteins control a myriad of fundamental cellular activities, including cell locomotion, intracellular transport, endo- and exocytosis. Dysfunction of cytoskeletal components is often associated with devastating diseases, such as cancer and several muscular, immune and neurodegenerative disorders.
Cytoskeletal proteins often form large functional assemblies, and additionally associate with cellular membranes. Therefore, our goal is to study their structures and activities within the context of such protein-protein and protein-membrane interaction networks. An important tool in our research is X-ray crystallography. The atomic “snapshots” resulting from crystal structures provide a wealth of knowledge, but lack information about the dynamic aspects of protein function. To obtain this kind of information we use a host of other approaches, including molecular biology, bioinformatics, biophysical methods (ITC, MALS, FRET, TIRF, Cryo-EM), and cell biology.
My laboratory studies the proteins that control the actin cytoskeleton and cytoskeleton-membrane connections, as well as the signaling cascades that regulate their activities. We use a broad spectrum of experimental approaches, spanning structural biology, biochemistry and cell biology, allowing us to correlate structure to function.
Cytoskeletal proteins control a myriad of fundamental cellular activities, including cell locomotion, intracellular transport, endo- and exocytosis. Dysfunction of cytoskeletal components is often associated with devastating diseases, such as cancer and several muscular, immune and neurodegenerative disorders.
Cytoskeletal proteins often form large functional assemblies, and additionally associate with cellular membranes. Therefore, our goal is to study their structures and activities within the context of such protein-protein and protein-membrane interaction networks. An important tool in our research is X-ray crystallography. The atomic “snapshots” resulting from crystal structures provide a wealth of knowledge, but lack information about the dynamic aspects of protein function. To obtain this kind of information we use a host of other approaches, including molecular biology, bioinformatics, biophysical methods (ITC, MALS, FRET, TIRF, Cryo-EM), and cell biology.
研究兴趣
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Nynke A. Veprek,Madeline H. Cooper,Laura Laprell,Emily Jie-Ning Yang, Sander Folkerts,Ruiyang Bao,Malgorzata Boczkowska, Nicholas J. Palmer,Roberto Dominguez,Thomas G. Oertner,Liza A. Pon,J. Bradley Zuchero,
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 13 (2024): 8895-8903
Rachel H Ceron, Faviolla A Báez-Cruz, Nicholas J Palmer,Peter J Carman,Malgorzata Boczkowska,Robert O Heuckeroth,E Michael Ostap,Roberto Dominguez
Science advancesno. 22 (2024): eadn6615-eadn6615
bioRxiv : the preprint server for biology (2024)
Nature (2024)
The Journal of biological chemistryno. 2 (2023): 102906-102906
CYTOSKELETONno. 9-10 (2023): 309-312
Nature communicationsno. 1 (2023): 6894
Science (New York, N.Y.)no. 6651 (2023): 1287-1292
Elana E Baltrusaitis, Erika E Ravitch,Adam R Fenton, Tania A Perez,Erika L F Holzbaur,Roberto Dominguez
The Journal of biological chemistryno. 12 (2023): 105441-105441
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