基本信息
浏览量:91
职业迁徙
个人简介
Dr. Sander’s Research
Cognitive Disintegration in Delirium
Delirium is a sudden state of confusion, associated with increased morbidity and mortality, impaired long-term cognition and loss of independence. Unfortunately, delirium is bereft of therapies, largely due to the limited understanding of its pathogenesis. The long-term goal of the proposed research program is to develop preventative and therapeutic approaches to delirium. In this application, I seek to identify the neural correlates of delirium, and subsequent cognitive decline, as the first step in a translational research program. The strategy is based on the Cognitive Disintegration model: we hypothesize that delirium results from an acute breakdown in neural network connectivity. In essence, delirium results when “information integration” falls below a critical threshold in vulnerable networks. We use network connectivity as a surrogate of the capacity to integrate information. We will test the hypothesis that impaired preoperative cingulate functional connectivity is associated with increased risk of postoperative delirium following adjustment for confounding variables. The electroencephalogram (EEG) hallmark of delirium is increased slow wave activity however the patients are not asleep. We hypothesize that there is “local” slow wave activity in delirium. If proven, this would provide a mechanism for the breakdown in network connectivity in delirium and highlight specific brain vulnerable regions producing the delirium state. Finally, we will address the role of pre-delirium connectivity in the associations between delirium and long-term cognitive decline, hypothesizing that preoperative connectivity modulates the impact of delirium on long-term cognition. This application will provide insights into the neural network changes predisposing to, and associated with, postoperative delirium and its long-term cognitive sequelae while providing key preliminary data for a future R01 application.
Cognitive Disintegration in Delirium
Delirium is a sudden state of confusion, associated with increased morbidity and mortality, impaired long-term cognition and loss of independence. Unfortunately, delirium is bereft of therapies, largely due to the limited understanding of its pathogenesis. The long-term goal of the proposed research program is to develop preventative and therapeutic approaches to delirium. In this application, I seek to identify the neural correlates of delirium, and subsequent cognitive decline, as the first step in a translational research program. The strategy is based on the Cognitive Disintegration model: we hypothesize that delirium results from an acute breakdown in neural network connectivity. In essence, delirium results when “information integration” falls below a critical threshold in vulnerable networks. We use network connectivity as a surrogate of the capacity to integrate information. We will test the hypothesis that impaired preoperative cingulate functional connectivity is associated with increased risk of postoperative delirium following adjustment for confounding variables. The electroencephalogram (EEG) hallmark of delirium is increased slow wave activity however the patients are not asleep. We hypothesize that there is “local” slow wave activity in delirium. If proven, this would provide a mechanism for the breakdown in network connectivity in delirium and highlight specific brain vulnerable regions producing the delirium state. Finally, we will address the role of pre-delirium connectivity in the associations between delirium and long-term cognitive decline, hypothesizing that preoperative connectivity modulates the impact of delirium on long-term cognition. This application will provide insights into the neural network changes predisposing to, and associated with, postoperative delirium and its long-term cognitive sequelae while providing key preliminary data for a future R01 application.
研究兴趣
论文共 60 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Heidi Lindroth,Lisa Bratzke,Sara Twadell,Paul Rowley, Janie Kildow, Mara Danner, Lily Turner,Brandon Hernandez,Roger Brown,Robert D Sanders
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn