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职业迁徙
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The overarching research aim of my laboratory is to understand how a healthy eye is built and maintained throughout life. More specifically, we are interested in how glial cells, the major support cells in the nervous system, are patterned and shaped during development to support neurons. We are also interested in what happens when the intricate glia-neuronal relationship breaks down due to increasing age or disease.
The retina is the light sensitive part of the eye that allows you to see. We use the zebrafish retina as a model as it contains the same neuron types and glial cells as the human eye. The zebrafish embryo is an incredible system to study development – it is transparent, we can label each cell with specific fluorescent markers and use time-lapse confocal microscopy to watch eye development happen in real time in a living fish! In addition to imaging we use CRISPR/Cas9 mutagenesis, RNA-sequencing and molecular biology to uncover and explore fundamental mechanisms of glial biology.
We are now interested in determining the cellular and molecular mechanisms regulating glial morphogenesis, with a particular focus on the consequences of disrupted glial contacts on neuronal function.
The retina is the light sensitive part of the eye that allows you to see. We use the zebrafish retina as a model as it contains the same neuron types and glial cells as the human eye. The zebrafish embryo is an incredible system to study development – it is transparent, we can label each cell with specific fluorescent markers and use time-lapse confocal microscopy to watch eye development happen in real time in a living fish! In addition to imaging we use CRISPR/Cas9 mutagenesis, RNA-sequencing and molecular biology to uncover and explore fundamental mechanisms of glial biology.
We are now interested in determining the cellular and molecular mechanisms regulating glial morphogenesis, with a particular focus on the consequences of disrupted glial contacts on neuronal function.
研究兴趣
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Aanandita Kothurkar, Gregory S. Patient,Nicole C. L. Noel, Aleksandra M Krzywańska, Brittany J. Carr,Colin J. Chu,Ryan B. MacDonald
biorxiv(2024)
Steven Bergmans, Nicole C L Noel,Luca Masin, Ellen G Harding, Aleksandra M Krzywańska, Julie D De Schutter,Rajagopal Ayana,Chi-Kuo Hu, Lut Arckens,Philip A Ruzycki,Ryan B MacDonald, Brian S Clark,
Aging cellpp.e14192-e14192, (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Current protocolsno. 1 (2023)
Disease models & mechanismsno. 6 (2023)
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