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My laboratory is interested in the structure and function of membrane proteins, in particular the chloride/bicarbonate anion exchanger (AE1, Band 3). The Band 3 glycoprotein of the erythrocyte membrane is responsible for the exchange of chloride and bicarbonate across the plasma membrane, a process necessary for respiration. A truncated form of the protein (kAE1) is expressed in the kidney where it plays an essential role in bicarbonate re-absorption.
A major aim of our research is to determine, at the molecular level, the mechanism of action of the human chloride/bicarbonate anion exchanger (AE1) and a truncated version kAE1, expressed in the kidney. We are also interested in determining the effect of mutations in the AE1 (SLC4A1) gene, linked to various hematological and kidney diseases, on the biosynthesis and function of the protein. A wide variety of structural, cellular and molecular biological techniques are employed in our research.
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Biographical Memoirs of Fellows of the Royal Society (2021): 317-333
Reinhart Reithmeier, Liam O'Leary, Xiaoyue Zhu, Corey Dales, Abokor Abdulkarim, Anum Aquil, Lochin Brouillard, Samantha Chang, Samantha Miller,Wenyangzi Shi, Nancy Vu, Chang Zou
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