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Advances in the understanding and development of CRISPR-Cas systems have revolutionized the gene editing methods in biology and medicine. However, the imperfect properties of current CRISPR-Cas technology, such as a high off-target rate, a strict PAM requirement, high cell toxicity, and large gene size, restrict its diverse applications. We aim to discover, characterize, and engineer new CRISPR-Cas systems with superior properties compared with current CRISPR-Cas systems. In addition, we leverage different CRISPR-Cas systems to develop rapid and efficient gene editing tools in major human pathogens to facilitate fundamental understanding of infection and drug-resistance mechanisms. Finally, we aim to develop CRISPR-based antimicrobial strategies to counter infections caused by drug-resistant human pathogens.
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论文共 80 篇作者统计合作学者相似作者
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Hongyuan Zhang,Jiacheng Ma,Zhaowei Wu, Xiaoyang Chen, Yangyang Qian,Weizhong Chen,Zhipeng Wang,Ya Zhang,Huanhu Zhu,Xingxu Huang,Quanjiang Ji
Nature Communicationsno. 1 (2024): 1-9
Methods in molecular biology (Clifton, N.J.) (2024): 3-12
Cold Spring Harbor protocols (2023)
Angewandte Chemie International Editionno. 5 (2023)
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Cold Spring Harbor protocols (2023)
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ACS synthetic biologyno. 1 (2023): 269-281
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