The research in Wang group is divided into four distinctive but inter-connected topics: (1) chemoselective functionalization of bionanoparticles (BNPs); (2) self-assembly of BNPs towards materials development; (3) cell-recognition study with BNP-assemblies; and (4) fluorogenic reaction for protein imaging and recognition. All these researches point to one direction: to build three-dimensional programmable scaffolds that mimic the native extracellular matrices and can be used to probe the cellular activities.