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The major research thrusts in the Mali laboratory can be categorized as follows: one, development of genome and transcriptome engineering toolsets and their application to systematic genome interpretation and gene therapy applications; and two, study and engineering of gene regulatory networks and cellular niches governing cell fate specification during development utilizing human pluripotent stem cells as the core model system. Given the parallels in phenotypes (such as self-renewal and tumor forming ability) between pluripotent stem cells and cancer cells, a key research thrust is also in dissecting aberrant cellular transformation processes such as during tumorigenesis. As such, the research program lies at the interface of technology development and basic science, and combines core expertise in synthetic biology and regenerative medicine, with instrumentation and materials engineering.
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论文共 143 篇作者统计合作学者相似作者
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Dong Jun Park, Wooil Choi, Sakeef Sayeed,Robert A. Dorschner,Joseph Rainaldi,Kayla Ho, Jenny Kezios,John P. Nolan,Prashant Mali,Todd Costantini,Brian P. Eliceiri
Molecular Therapy (2024)
Shankar Subramaniam, Metin Akay, Mark A Anastasio, Vasudev Bailey, David Boas,Paolo Bonato,Ashutosh Chilkoti,Jennifer R Cochran, Vicki Colvin,Tejal A Desai,James S Duncan, Frederick H Epstein,
IEEE Open Journal of Engineering in Medicine and Biology (2024): 1-13
Kivilcim Ozturk,Rebecca Panwala, Jeanna Sheen,Kyle Ford, Nathan Jayne,Dong-Er Zhang, Stephan Hutter, Torsten Haferlach,Trey Ideker,Prashant Mali,Hannah Carter
Cancer Researchno. 6_Supplement (2024): 4899-4899
Nature Biomedical Engineeringno. 2 (2024): 111-113
crossref(2023)
CANCER RESEARCHno. 8 (2023)
Karina Barbosa,Anagha Deshpande, Marlenne Perales,Ping Xiang,Rabi Murad, Akula Bala Pramod,Anna Minkina,Neil Robertson,Fiorella Schischlik,Xue Lei,Younguk Sun,Adam Brown,
Bloodno. 8 (2023): 697-712
bioRxiv : the preprint server for biology (2023)
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