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Over time he moved his studies from molecules to in vivo models, studying biophysics, peptide design, lipid synthesis and enzymology, and cell and molecular biology. His work is centered on high density lipoprotein therapeutics, and energy metabolism as it relates to obesity-linked diabetes and human lipid metabolism. A major goal of his research is to determine how alcohol ingestion contributes to enhanced postprandial lipemia, attendant pancreatitis, or alcohol-induced reduction of cardiovascular disease, an effect mediated by increased HDL-cholesterol.
His research is multidisciplinary, with extensive collaboration with structural biologists, endocrinologists, and x-ray crystallographers. Structural biologists provide expertise in lipid and lipoprotein structure by electron cryo microscopy. Endocrinologists have synergistic interests in the lipid disorders found in HIV-positive patients on highly active anti retroviral therapies. X-ray crystallographers help discern the total structure of Streptococcal serum opacity factor (SOF) for determination of structure function relationships.
Dr. Pownall maintains an active academic program. He is a member of three graduate programs at Baylor College of Medicine (Structural Computational Biology and Molecular Biophysics, Cell and Molecular Biology, and Cardiovascular Sciences) in which he teaches classes and serves on graduate advisory and qualifying exams committees. He is also active in community education, giving lectures on molecular ethics to local groups including several churches, home owner associations and garden clubs.
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Current opinion in lipidologyno. 6 (2023): 278-286
Arteriosclerosis, Thrombosis, and Vascular Biologyno. Suppl_1 (2022)
Sivareddy Kotla,Masaki Imanishi,Shengyu Li,Aijun Zhang, Kyung A. Ko,Venkata Subrahman K. Samanthapudi, Ling-Ling Lee,Joerg Herrmann,Steven Lin, Michael N. Shoykhet,Ying H. Shen, Keri Schadler,
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Shengyu Li,Sivareddy Kotla,Masaki Imanishi,Kyung Ae Ko, Venkatasubrahman Samanthapudi,Hannah Savage,Keri Schadler,Anita Deswal,Steven Lin,Cielito Reyes-Gibby,Sai-Ching Yeung,Henry J Pownall,
Arteriosclerosis, Thrombosis, and Vascular Biologyno. Suppl_1 (2022)
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