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PGB’s expertise in Medicinal Chemistry is recognized by the important scientific production consisting in more than 390 publications including 50 patents (Hirsch factor = 47). His main research fields are the synthesis of natural product endowed with biological activity, prostaglandins, minor groove binder as alkylating agents with antitumor activity (Anthramycins, Distamycins and CC-1065 analogues), antiviral agents, agonists and antagonists for A2A, A2B and A3 adenosine receptors, new antitumor compounds inhibiting tubulin polymerization (combretastatin analogues) and TRPV1/TRPA1 ligands. PGB is co-founder, with Prof. Geppetti and Prof. Borea, of the private biopharmaceutical company PharmEste focused on the discovery and development of Transient Receptor Potential (TRPV1) vanilloids channel therapeutics. In collaboration with Prof. Geppetti, his interest is now embracing the investigation of new ligands, expecially antagonists, for the TRPA1 receptor as potential therapeutic target.
研究兴趣
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The Adenosine Receptorspp.169-198, (2018)
Medicinal Research Reviewsno. 4 (2018)
The Adenosine Receptorspp.91-136, (2018)
HANDBOOK OF CANNABIS AND RELATED PATHOLOGIES: BIOLOGY, PHARMACOLOGY, DIAGNOSIS, AND TREATMENTpp.592-605, (2017)
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