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Sex steroids are master regulators of health in men and women. Sites of synthesis vary across the life course with the gonads (testis, ovaries) being the major site of synthesis after puberty. In older individual’s synthesis by the adrenals and peripheral tissues such as fat become more important. Steroids can regulate tissue function by binding to receptors that function as ligand activated transcription factors within the nucleus and cell-specific effects are fine tuned by recruitment of a 'cocktail' of co-factors. Steroid receptors, including those that recognise oestrogens, may also participate in membrane-initiated steroid signaling (MISS) pathways which are typically rapid and thought to be important for vascular function. Sex steroids have both direct and indirect effects on immune cells and inflammatory processes and can contribute to differences in response to infection or tissue damage in men and women.
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论文共 47 篇作者统计合作学者相似作者
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CANCER RESEARCHno. 11 (2023)
Frontiers in reproductive health (2023): 1158317-1158317
Cell reports. Medicineno. 9 (2023): 101192-101192
Kevin K W Kuan,Philippa T K Saunders
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2020)
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2019)
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