基本信息
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职业迁徙
个人简介
Dr. Low has spent over 45 years exploring:
targeted therapeutic and imaging agents for multiple human diseases (including several cancers, autoimmune, infectious, and inflammatory diseases),
the structure, function, and pathologies of the erythrocyte membrane, and
signal transduction across plant cell membranes.
Cancer Therapeutics
We target drugs to cancer cells by attaching them to ligands that bind with high specificity for a receptor on cancer cells. By concentrating the anti-cancer drug in the malignant cells, we improve both drug potency and toxicity. Eight ligand-targeted drugs from our lab are currently in human clinical trials and the same tumor-specific targeting ligands are being used to target CAR T cells specifically to tumor tissues. Along similar lines, we are targeting immune modulators to specific immune cell types for the purpose of reprogramming these cells from a tumor-supporting to tumor-killing phenotype.
研究兴趣
论文共 477 篇作者统计合作学者相似作者
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Ramesh Mukkamala, Lindemann D. Spencer, Carlson J. Daniel, Pooja Tudi, Miller Nicholas Kaine, Autumn Horner,Srinivasarao Madduri,Philip S. Low
Cancer Researchno. 6_Supplement (2024): 1119-1119
Ahmed M. Abdelaal, Ikjot S. Sohal, Shreyas G. Iyer, Kasireddy Sudarshan,Esteban A. Orellana, Kenan E. Ozcan, Andrea P. dos Santos,Philip S. Low,Andrea L. Kasinski
Jeffery J Nielsen,Stewart A Low,Christopher Chen, Xinlan Li, Ephraim Mbachu, Lina Trigg, Siyuan Sun, Madeline Tremby, Rahul Hadap,Philip S Low
Biomedicinesno. 3 (2024)
Patrick Bou-Samra,Austin Chang, Emily Guo,Feredun Azari,Gregory Kennedy,Azra Din,Taine Pechet, Doraid Jarrar,John Kucharczuk, Jarrod Predina, James Delikatny,Philip S. Low,
Annals of Thoracic Surgery Short Reports (2024)
Joshua Pace,Madduri Srinivasarao, Shivakrishna Kallepu,Riley Whalen, Heather Theison, Grace Hubbell,Lei G. Wang,Melissa H. Wong,Summer L. Gibbs,Philip S. Low,Mark Niedre
Molecular-Guided Surgery: Molecules, Devices, and Applications X (2024)
CANCER RESEARCHno. 7 (2023)
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Jeffery Nielsen,Stewart Low,Mini Thomas,Mary Niedrauer, Xinlan Li,Christopher Chen,Ephraim Mbachu, Lina Trig, Madeline Tremblay,Philip Low
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 303-304
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Spencer D Lindeman,Ramesh Mukkamala, Autumn Horner, Pooja Tudi, Owen C Booth, Roxanne Huff, Joshua Hinsey, Anders Hovstadius, Peter Martone,Fenghua Zhang,Madduri Srinivasarao,Abigail Cox,
Journal of nuclear medicine : official publication, Society of Nuclear Medicineno. 5 (2023): 759-766
Rami Alfar,John V. Napoleon,Imrul Shahriar,Richard Finnell, Cole Walchle, Austin Johnson,Philip S. Low
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ONCOLOGY-NEW YORKno. 2 (2023): 53-54
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