基本信息
浏览量:3
职业迁徙
个人简介
Research
An investigation of the effect of H2S on atherosclerosis
We have previously reported that H2S exhibits potent vasodilator and anti-inflammatory activity suggesting that this novel gas may play a part in cardiovascular physiology and pathophysiology. This project seeks to determine whether a deficiency of vasculoprotective H2S may precipitate atherosclerotic disease. Experiments will be carried out in ApoE-/- atherosclerotic mice and combined with investigation of blood vessels obtained from human volunteers collected, after informed consent, during coronary artery surgery. The project centres upon an integrative approach involving studies both in animals and in cell culture.
A study of the biological effects of novel H2S donor drugs
A number of projects are currently under way to determine the biological effects of a range of novel H2S donor agents in inflammation and cardiovascular disease. Possible target for these drugs which are currently being studied include lipopolysaccharide-evoked septic shock and adjuvant-induced knee joint arthritis. A range of techniques including cell culture and associated biochemical and molecular biological characterisation as well as studies in intact animals are ongoing.
研究兴趣
论文共 277 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
William Thomas Christopher Procter,James Elliott, Abdul H. Butt, Christopher Monkhouse,Anish N. Bhuva,Philip Moore
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2023)
Antonio Creta, Nicoletta Ventrella,Mark J Earley,Malcolm Finlay,Simon Sporton, Edward Maclean,Vijayabharathy Kanthasamy, Bruna Costa Lemos Silva Di Nubila,Danilo Ricciardi,Vito Calabrese,Francesco Picarelli,Ross J Hunter,
JACC. Clinical electrophysiologyno. 1 (2023): 121-132
Daniel Keene,Nandita Kaza,Ahran Arnold,James P. Howard,Mark Tanner,Paul Foley,Badri Chandrasekaran,Philip Moore, Silvia Bassi,Amal Muthumala, Shouvanik Adhya,Sharad Agarwal,
引用1浏览0引用
1
0
Christopher A. Monkhouse,Amy Louise Wharmby, Amal G. Muthumala,Philip Moore,Syed Ahsan,Michele Orini,Pier D. Lambiase
Heart Rhythmno. 5 (2022): S64-S65
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn