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Hanawalt was a productive researcher in the field of DNA repair since his pioneering discovery of repair replication and co-discovery of nucleotide excision repair in E. coli in 1963. In 1982 Hanawalt and his colleagues reported the first example of intragenomic DNA repair heterogeneity: chemical adducts in alpha DNA in African green monkey kidney cells were not as efficiently repaired as in the genome overall. Hanawalt and his colleagues then discovered that repair of some types of damage is selective; active genes are preferentially repaired, and in fact a special repair pathway, termed transcription-coupled repair (TCR), operates on the transcribed strands of expressed genes. TCR was documented in mammalian cells, in E. coli, and in yeast chromosomal and plasmid borne genes. The discovery of TCR in Hanawalt laboratory has had profound implications for the fields of mutagenesis, environmental carcinogenesis, aging, and risk assessment.
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Joann B. Sweasy,Philip C. Hanawalt
Life (Basel, Switzerland)no. 4 (2023): 1052-1052
DNA REPAIR (2020): 102933-102933
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