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个人简介
Beginning with his graduate work, through his post-doc, and into his independent career, Phil has focused on obtaining molecular insights into the myriad roles of RNA in biology through mechanistic approaches. The Bevilacqua lab has diverse interests in RNA that include ribozyme mechanism, pathways for RNA folding in vivo, RNA structure in living organisms, and roles for RNA on early Earth. His lab has introduced new approaches to study RNA, often in a collaborative fashion, including pKa measurements by diverse means; use of conformationally restricted nucleotides to probe RNA structure and function; probing of RNA folding across an entire transcriptome in vivo; and compartmentalizing and studying RNA function. The lab uses computational chemistry approaches in all aspects of its research including Statistical Thermodynamics, Bioinformatics and Cheminformatics, and Molecular Dynamics and QM/MM. New insights from these studies include demonstrations of active roles for nucleobases in RNA catalysis (‘nucleobase catalysis’), identification of functions for in vivo RNA structure in RNA processing events, and elucidation of RNA determinants for innate immune responses (PAMPs) at the primary, secondary, and tertiary RNA structural levels. Phil lives in State College, PA where he enjoys spending time outdoors fly fishing the limestone streams and biking the rolling hills of central PA. He and his wife Jo have three girls, Sarah, Erin, and Chloe.
研究兴趣
论文共 257 篇作者统计合作学者相似作者
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Elizabeth A. Jolley,Philip C. Bevilacqua
Nature Methodsno. 3 (2024): 377-378
bioRxiv : the preprint server for biology (2023)
Allison M Williams, Elizabeth A Jolley,Michel Geovanni Santiago-Martínez,Cheong Xin Chan, Robin R Gutell,James G Ferry,Philip C Bevilacqua
RNA (New York, N.Y.)no. 10 (2023): 1610-1620
Nucleic acids researchno. 20 (2023): 11298-11317
Biophysical Reportsno. 2 (2023): 100101-100101
Allison M. Williams, Elizabeth A. Jolley,Michel Geovanni Santiago-Martínez,Cheong Xin Chan,Robin R. Gutell, James G. Ferry,Philip C. Bevilacqua
bioRxiv (Cold Spring Harbor Laboratory)no. 10 (2023): 1610-1620
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Methods in Enzymology (2023): 81-126
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