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In his early studies, he showed that transferrin binds many other metals in addition to iron; his lab clarified the dependency of metal binding and release on the binding of anions such as bicarbonate. Later, in a highly cited work, he demonstrated that the two binding sites of transferrin have different affinities and were cooperative despite being 45 Angstroms apart.
He went on to study the interactions of transferrin with its receptor and, in a seminal work, demonstrated that the receptor modulated the release of iron from transferrin in the cell. After filling in many more details of transferrin function, he collaborated with Dr. Tomas Walz, at Harvard, and reported the structure of the transferrin/transferrin receptor complex, confirming many inferences he’d made based on his biochemical studies.
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Nicholas Noinaj, Nicole C. Easley,Muse Oke,Naoko Mizuno,James Gumbart,Evzen Boura,Ashley N. Steere,Olga Zak,Philip Aisen,Emad Tajkhorshid, Robert W. Evans,Andrew R. Gorringe,
The international journal of biochemistry & cell biologyno. 11 (2004): 2137-43
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