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Our interests have their origins in primary research of the molecular biology, cellular biochemistry and proteomics of vacuolar function with special emphasis on membrane transport proteins and the enzymatic machinery responsible for the detoxification of xenobiotics, especially heavy metals. The long-term objectives of these investigations were to identify the proteins concerned and elucidate their mechanisms of action and regulatory characteristics. The approach taken was that of the 'basic biologist' – the search for general principles, regardless of the organism in which they are to be elucidated, not just principles applicable to plants. Many of the investigations conducted therefore entailed parallel molecular and biochemical manipulations of several model systems including the plant Arabidopsis thaliana, the yeast Saccharomyces cerevisiae and the nematode worm Caenorhabditis elegans. It is by this approach that we were able to make fundamental contributions toward understanding a remarkably broad range of transport and related phenomena of general significance. Working from this background in primary research, in combination with an increased involvement with the communication of science to the educated lay public, our current research efforts are directed toward explaining some of the largely untold stories behind discoveries in the life sciences that have had or may prove to have an unprecedented impact on our lives or the lives of others.
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Annual Plant Reviews onlinepp.234-267, (2018)
Philip A. Rea, Anderson Y. Tien
Plant Organelles Compartmentation of Metabolism in Photosynthetic Cellspp.169-188, (2011)
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Journal of Biological Chemistryno. 1 (2009): 354-362
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