基本信息
浏览量:25
职业迁徙
个人简介
The research in my group is broadly concerned with many-body phenomena in biology, chemistry and physics. A major theme is understanding systems where a large diversity of long-lived states is involved, necessitating the use of a statistical characterization of an energy or attractor landscape. The most notable examples are glasses, liquids, biomolecules and biomolecular regulatory networks. In the area of protein folding we are interested both in describing folding kinetics in the laboratory and the development of bioinformatically based schemes for predicting structure from sequence using computer simulation. A key concept is that the energy landscape of a foldable protein looks like a rugged funnel. This idea guides the development of both simple folding kinetics models and structure prediction algorithms. Similar issues of attractor landscapes also arise in higher order biological processes, such as gene recognition and genetic network regulation, which we also study. The energy landscapes of supercooled liquids and glasses also present interesting problems. We have shown how a new approach based on "random first order transitions" explains many quantitative relations found empirically both in liquids and under cryogenic conditions where quantum effects play a role. The same ideas show promise in the study of systems as different as high temperature superconductors, polymer assemblies, and microemulsions. They are also useful for describing the three-dimensional structure and dynamics of chromosomes and the interior of living cells.
研究兴趣
论文共 492 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Wei Lu,Jixian Zhang,Weifeng Huang,Ziqiao Zhang, Xiangyu Jia, Zhenyu Wang, Leilei Shi,Chengtao Li,Peter G. Wolynes,Shuangjia Zheng
Nature Communicationsno. 1 (2024): 1-13
R. Gonzalo Parra,Maria Freiberger, Miriam Poley-Gil, Miguel Fernandez-Martin,Leandro G. Radusky, Victoria Ruiz-Serra,Peter G. Wolynes,Diego U. Ferreiro,Alfonso Valencia
arxiv(2024)
引用0浏览0引用
0
0
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 15 (2024): e2321668121-e2321668121
Nature communicationsno. 1 (2023): 8379-8379
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 52 (2023): e2319705120-e2319705120
biorxiv(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn