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职业迁徙
个人简介
My lab is using functional genomics, molecular biology, biochemistry, and advanced imaging in both the yeast model and cultured human cells to study fundamental mechanisms of genome maintenance and stability. Failure to maintain genome integrity leads to mutations that can promote tumour formation. Normal genome maintenance mechanisms can be overwhelmed by carcinogen exposure, or the presence of germline or somatic variants that induce genomic instability. Our work is aimed at determining the causes of genomic instability as an enabling characteristic of tumour formation, and exploring the potential of these early events to suggest novel therapeutic targets. Currently, we are working on several projects, briefly outlined below.
Roles of RNA processing in genome maintenance
DNA repair: mutation signatures and transcription-replication conflicts
The global cellular response to genotoxic stress
Roles of RNA processing in genome maintenance
DNA repair: mutation signatures and transcription-replication conflicts
The global cellular response to genotoxic stress
研究兴趣
论文共 73 篇作者统计合作学者相似作者
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Nature communicationsno. 1 (2024): 3215-3215
Leanne Amitzi, Ecaterina Cozma,Amy Hin Yan Tong,Katherine Chan,Catherine Ross, Nigel O'Neil,Jason Moffat,Peter Stirling, Philip Hieter
G3 (Bethesda, Md.) (2024)
Leticia Dinatto,Peter C Stirling
Molecular cellno. 13 (2023): 2161-2163
Louis-Alexandre Fournier, Forouh Kalantari,James P Wells,Joon S Lee, Genny Trigo-Gonzalez,Michelle M Moksa,Theodore Smith,Justin White, Alynn Shanks,Linda Wang, Edmund Su,Yemin Wang,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Sunny Y Yang, Emily Y C Chang, Joanne Lim, Harwood H Kwan,David Monchaud,Stephen Yip,Peter C Stirling,Judy M Y Wong
NAR cancerno. 3 (2021)
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