基本信息
浏览量:4
职业迁徙
个人简介
I completed a PhD in muscle regeneration at King’s College London, before working on gene regulation and heart development with Professor Margaret Buckingham at the Pasteur Institute (Paris). Next, I worked with Professor Terence Partridge investigating muscle stem cells at Imperial College London, before starting my own group at King’s College London in 2005.
My core research is directed at understanding how muscle satellite cells are regulated in healthy and diseased skeletal muscle and their roles in cancer. Skeletal muscle is an archetypal adult stem cell model, in which maintenance, growth and repair of functionally specialised post-mitotic cells is achieved by recruitment of undifferentiated precursors. The functional unit of a skeletal muscle is the myofibre: a giant syncytial cell maintained by hundreds of post-mitotic myonuclei. The routine needs for myonuclear homeostasis, together with the more sporadic demands for hypertrophy and repair, are performed by muscle satellite cells. These resident stem cells are normally mitotically quiescent in mature muscle, and so must first be activated to undergo extensive proliferation to generate myoblasts that eventually differentiate to provide new myonuclei. In muscle wasting diseases such as muscular dystrophies though, this regenerative capacity is gradually degraded.
Current research in the group includes investigating the contribution of satellite cell dysfunction and mechanisms of disease progression in Facioscapulohumeral muscular dystrophy and Emery-Dreifuss muscular dystrophy, together with developing potential therapies. We also have an interest in rhabdomyosarcoma: cancer that exhibits myogenic traits.
My core research is directed at understanding how muscle satellite cells are regulated in healthy and diseased skeletal muscle and their roles in cancer. Skeletal muscle is an archetypal adult stem cell model, in which maintenance, growth and repair of functionally specialised post-mitotic cells is achieved by recruitment of undifferentiated precursors. The functional unit of a skeletal muscle is the myofibre: a giant syncytial cell maintained by hundreds of post-mitotic myonuclei. The routine needs for myonuclear homeostasis, together with the more sporadic demands for hypertrophy and repair, are performed by muscle satellite cells. These resident stem cells are normally mitotically quiescent in mature muscle, and so must first be activated to undergo extensive proliferation to generate myoblasts that eventually differentiate to provide new myonuclei. In muscle wasting diseases such as muscular dystrophies though, this regenerative capacity is gradually degraded.
Current research in the group includes investigating the contribution of satellite cell dysfunction and mechanisms of disease progression in Facioscapulohumeral muscular dystrophy and Emery-Dreifuss muscular dystrophy, together with developing potential therapies. We also have an interest in rhabdomyosarcoma: cancer that exhibits myogenic traits.
研究兴趣
论文共 113 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
HUMAN MOLECULAR GENETICSno. 2 (2024): 182-197
Cell and Tissue Researchno. 3 (2024): 271-283
Marius Meinhold,Sander Verbrugge,Andi Shi, Martin Schoenfelder,Lore Becker,Richard T. Jaspers,Peter S. Zammit,Henning Wackerhage
CELL AND TISSUE RESEARCH (2024)
Thuy-Hang Nguyen, Lise Paprzycki,Alexandre Legrand,Anne-Emilie Declèves,Philipp Heher, Maelle Limpens,Alexandra Belayew,Christopher R. S. Banerji,Peter S. Zammit,Alexandra Tassin
Skeletal Muscleno. 1 (2023): 1-14
引用0浏览0WOS引用
0
0
Thuy-Hang Nguyen, Lise Paprzycki,Alexandre Legrand,Anne-Emilie Decleves,Philipp Heher, Maelle Limpens,Alexandra Belayew, Christopher R. S. Banerji,Peter S. Zammit,Alexandra Tassin
SKELETAL MUSCLEno. 1 (2023)
Free Radical Biology and Medicine (2023): S10-S10
引用0浏览0引用
0
0
medrxiv(2023)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn