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The McPherson laboratory uses biochemical, molecular, structural, genetic and cellular approaches to identify and functionally characterize proteins that operate in the formation of clathrin-coated vesicles (CCVs). CCVs are the major vehicles for endocytic uptake of multiple protein and lipid cargo including nutrient and signaling receptors. Following endocytosis, cargo is delivered to endosomes from where it either recycles back to the cell surface or is targeted to lysosomes for degradation. These sorting decisions control the localization and levels of proteins and are altered in cancer and neurological disease. For example, current projects in the lab reveal how disruption in transport of selective cargo from endosomes to the cell surface contributes to the development of glioblastoma and breast cancer.
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论文共 340 篇作者统计合作学者相似作者
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medRxiv : the preprint server for health sciences (2024)
Maryam Fotouhi, Donovan Worrall,Riham Ayoubi, Kathleen Southern,Peter S McPherson,Carl Laflamme, NeuroSGC/YCharOS/EDDU collaborative group, ABIF Consortium
F1000Research (2024): 745-745
Riham Ayoubi,Joel Ryan,Sara Gonzalez Bolivar, Charles Alende, Vera Ruiz Moleon,Maryam Fotouhi, Kathleen Southern,Walaa Alshafie, Matt R Baker, Alexander R Ball, Danielle Callahan, Jeffery A Cooper,
crossref(2024)
F1000Research (2024)
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Adriana Aguila,Somaya Salah,Gopinath Kulasekaran, Moatasem Shweiki, Nava Shaul-Lotan,Hagar Mor-Shaked, Muhannad Daana,Tamar Harel,Peter S. McPherson
Journal of Biological Chemistrypp.107124-107124, (2024)
Nature Communicationsno. 1 (2024): 1-18
Zenodo (CERN European Organization for Nuclear Research) (2023)
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Zenodo (CERN European Organization for Nuclear Research) (2023)
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Zenodo (CERN European Organization for Nuclear Research) (2023)
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Riham Ayoubi,Maryam Fotouhi, Vera Ruíz Moleón,Joël Ryan, Donovan Worrall,Wolfgang Reintsch,Thomas M. Durcan,Claire M. Brown,Peter S. McPherson,Carl Laflamme
Zenodo (CERN European Organization for Nuclear Research) (2023)
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