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The Parham laboratory investigates the biology, genetics, and evolution of Major Histocompatibility Complex (MHC) class I molecules, natural killer (NK) cell receptors, and other immune system molecules. Classical MHC class I molecules are peptide-binding glycoproteins expressed on the surface of most vertebrate cells where they interact with the receptors of cytolytic CD8+ T lymphocytes and NK cells of the immune system. Both these types of killer lymphocytes are important for defence against viruses - generalised NK cell response at the beginning of infection, and specific T cell response further on if the pathogen is not eliminated by innate immunity. The rapid evolution of viruses selects for diversity of MHC class I molecules within populations of humans and other vertebrates.
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论文共 517 篇作者统计合作学者相似作者
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HLA: Immune Response Geneticsno. 1 (2023): 28-43
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HLAno. 4 (2023): 333-333
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Nolwenn Legrand, Perla Salameh,Maxime Jullien,Patrice Chevallier, Enora Ferron, Gaelle David,Marie-Claire Devilder,Catherine Willem,Ketevan Gendzekhadze,Peter Parham,Christelle Retiere,Katia Gagne
Transfusion Clinique et Biologique (2023): S41-S41
BIOCHEMICAL SOCIETY TRANSACTIONSno. 3 (2023): 1201-1212
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Nolwenn Legrand, Enora Ferron, Perla Salameh,Gaelle David,Marie-Claire Devilder,Catherine Willem,Ketevan Gendzekhadze,Peter Parham,Christelle Retiere,Katia Gagne
HLAno. 4 (2023): 419-420
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N. Legrand, P. Salameh,M. Jullien,P. Chevallier, E. Ferron,G. David, M. Devilder,C. Willem,K. Gendzekhadze,P. Parham,C. Retiere,K. Gagne
EUROPEAN JOURNAL OF IMMUNOLOGYno. 10 (2023): 181-181
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The Tabula Microcebus Consortium,Camille Ezran,Shixuan Liu,Jingsi Ming,Lisbeth A. Guethlein,Michael F.Z. Wang,Roozbeh Dehghannasiri,Julia Olivieri,Hannah K. Frank,Alexander Tarashansky,Winston Koh,Qiuyu Jing,
biorxiv(2022)
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