His current research interests include the development and application of hyphenated mass spectrometric, NMR spectroscopic and bioinformatics methods to the study of proteomes and metabolomes in cancer and kidney disease. Particular areas of interest are the role of tumor metabolism in tumor progression and immune escape as well as the learning of diagnostic and predictive molecular signatures from high-dimensional data. To date, he has co-authored 249 original publications, 34 reviews, and 28 book chapters. He holds five US patents, among others on denaturing high-performance liquid chromatography (dHPLC) for the detection of genetic variants in medical, microbial, plant, and population genetics.