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Peter has published over 80 research papers in scientific journals as well as reviews and book chapters in the fields of molecular immunology, leukaemia and chromatin structure. He has received major grants from Blood Cancer UK, the BBSRC, the MRC and various other funding bodies.
His research aims at defining mechanisms that control the development and activation of the immune system, and how these mechanisms are hijacked in myeloid leukaemia. These studies use the combined approaches of investigating chromatin structure in parallel with analyses of the DNA elements that control gene expression.
In the field of immunology, this has allowed the group to develop a comprehensive picture of the detailed mechanisms that allow cytokine genes to become activated in a tissue-specific manner in response to immune stimuli. He has defined the basic principles of how immunological memory is established by epigenetic mechanisms in response to a single vaccination of a specific antigen. He also demonstrated that the entire T cell homeostasis programme has to be shut down before memory T cells can be reactivated.
His research aims at defining mechanisms that control the development and activation of the immune system, and how these mechanisms are hijacked in myeloid leukaemia. These studies use the combined approaches of investigating chromatin structure in parallel with analyses of the DNA elements that control gene expression.
In the field of immunology, this has allowed the group to develop a comprehensive picture of the detailed mechanisms that allow cytokine genes to become activated in a tissue-specific manner in response to immune stimuli. He has defined the basic principles of how immunological memory is established by epigenetic mechanisms in response to a single vaccination of a specific antigen. He also demonstrated that the entire T cell homeostasis programme has to be shut down before memory T cells can be reactivated.
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Sandeep Potluri,Sophie G. Kellaway,Daniel J. L. Coleman,Peter Keane, Maria Rosaria Imperato,Salam A. Assi,Peter N. Cockerill,Constanze Bonifer
LEUKEMIAno. 2 (2024): 403-407
Sandeep Potluri,Sophie G. Kellaway,Daniel J. L. Coleman,Peter Keane, Maria Rosaria Imperato,Salam A. Assi,Peter N. Cockerill,Constanze Bonifer
Leukemiano. 2 (2024): 403-407
Daniel J.L. Coleman,Peter Keane,Paulynn S. Chin,Luke Ames,Sophie Kellaway,Helen Blair,Naeem Khan,James Griffin, Elizabeth Holmes, Alexander Maytum,Sandeep Potluri, Lara Strate,
iScienceno. 4 (2024): 109576-109576
Sophie G. Kellaway,Sandeep Potluri,Peter Keane,Helen J. Blair,Luke Ames, Alice Worker,Paulynn S. Chin,Anetta Ptasinska, Polina K. Derevyanko, Assunta Adamo,Daniel J. L. Coleman,Naeem Khan,
Nature communicationsno. 1 (2023): 6947-18
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