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个人简介
Dr Moyle's laboratory (www.moylelab.com) uses cutting edge technologies for the synthesis of peptides, protein expression, and protein semi-synthesis to gain insights into the functional roles played by various biochemical pathways, to engineer better protein and peptide therapeutics, and to improve the delivery characteristics of various therapeutic molecules. Specific current areas of interest are detailed below:
Subunit Vaccine Development: methods to develop improved vaccines through the combination of recombinant and synthetic approaches to improve immunopotency and tailor immune responses (links to reseach articles on semisynthetic vaccines and peptide vaccines; reviews on vaccine development).
Oligonucleotide Delivery Systems: multi-component synthetic approaches to improve the cellular uptake, and targeted delivery of various oligonucleotide molecules (e.g. siRNA and pDNA) as an exciting approach to treat or prevent various diseases (links to research articles and reviews).
Deciphering the Roles of Post-Translational Modifications: The combination of peptide synthesis and protein semisynthesis to enable the production of large amounts of site-specifically modified species, that can be used to deconvolute the roles played by various post-translational modifications (links to research articles).
Peptide/Protein Drugs and Delivery: The study of methods to improve the delivery characteristics of peptide/protein drugs (e.g. poor oral absorption, instability to chemical/enzymatic degradation, and the inability to reach their site/s of action) through chemical engineering approaches.
Subunit Vaccine Development: methods to develop improved vaccines through the combination of recombinant and synthetic approaches to improve immunopotency and tailor immune responses (links to reseach articles on semisynthetic vaccines and peptide vaccines; reviews on vaccine development).
Oligonucleotide Delivery Systems: multi-component synthetic approaches to improve the cellular uptake, and targeted delivery of various oligonucleotide molecules (e.g. siRNA and pDNA) as an exciting approach to treat or prevent various diseases (links to research articles and reviews).
Deciphering the Roles of Post-Translational Modifications: The combination of peptide synthesis and protein semisynthesis to enable the production of large amounts of site-specifically modified species, that can be used to deconvolute the roles played by various post-translational modifications (links to research articles).
Peptide/Protein Drugs and Delivery: The study of methods to improve the delivery characteristics of peptide/protein drugs (e.g. poor oral absorption, instability to chemical/enzymatic degradation, and the inability to reach their site/s of action) through chemical engineering approaches.
研究兴趣
论文共 90 篇作者统计合作学者相似作者
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Tania Rivera-Hernandez,Diane G Carnathan, Johanna Richter, Patrick Marchant,Amanda J Cork, Gayathiri Elangovan, Anna Henningham,Jason N Cole, Biswa Choudhury,Peter M Moyle, Istvan Toth,Michael R Batzloff,
Vaccinesno. 4 (2024): 382
Niwanthi W. Rajapakse, Haru Nomura,Melanie Wu,Jiangning Song,Andrew Hung, Shirley Tran,Hang T. Ta,Fahima Akther,Yuao Wu,Matt D. Johansen,Keng Yih Chew,Vinod Kumar,
Research Square (Research Square) (2023)
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Molecules (Basel, Switzerland)no. 5 (2023): 2114-2114
Drug delivery and translational researchno. 5 (2023): 1500-1519
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