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Dr. Soja's current research focuses on how synaptic transmission through identified ascending spinal sensory pathways and motoneuron pools differs during distinct behavioral states such as non-rapid eye movement (NREM) and REM sleep, or general anesthesia vs. wakefulness. Data derived from these studies will help to further elucidate the neural network interactions between sleep, pain, and anesthesia, which traditionally, have been studied as insular, separate fields. Moreover, these studies may provide targets for developing novel treatment approaches for the cataplexy associated with narcolepsy, the sensory dyesthesias of restless legs syndrome, and/or the abnormal motor tone that occurs in REM behavior disorder as well as chronic pain following restricted sleep, and/or recent CNS trauma.
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