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Our research is concerned with the optimal design and evaluation of aerosol drug delivery systems designed to target drugs to and via the lung. Effects of physical, chemical and formulation factors are studied, as well as the impact of the aerosol generation device. These factors are all related to our ability to deliver drugs by inhalation and target them to specific lung regions. Aerosols are characterized and evaluated in terms of particle size, shape, physical form and drug release characteristics in vitro and in vivo. In related research the effects of chemical structure and formulation variables are studied on absorption kinetics and lung disposition. Our biological research utilizes isolated lung preparations, whole animal studies and computer-based models to determine mechanisms of absorption, metabolism and retention for macromolecular and small molecular weight drugs.
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