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The primary focus of our laboratory over the years has been in deciphering signaling networks that promote cellular transformation and elucidating mechanisms that endow cancer cells the ability to evade execution. Our focus has been on identifying potential bottlenecks or vulnerabilities that cut across a spectrum of human cancers, and therefore our work includes hematopoietic malignancies as well as solid tumors, in particular, breast, colorectal, lung and pancreatic cancer. To that end, using a variety of model systems such as oncogene-induced proliferation, expression of apoptosis inhibitory proteins, pharmacological inhibition of key cellular metabolic regulators, receptor and chemotherapy-induced death stimuli, and novel small molecule compounds, we provide evidence that cellular redox metabolism critically impacts cell fate decisions. Of note, across a wide spectrum of cellular redox stress, there emerges a dichotomy of responses in terms of cell survival/proliferation and cell death. At the lower end of the scale cell survival and proliferation is favored, while at the other extreme cell execution is the preferred outcome. How these varied levels of stress evoke disparate biological responses with distinct functional outcome(s) and the signaling networks and potential cellular targets that could be amenable to redox modification(s) are the major focus of our ongoing and future investigations
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论文共 134 篇作者统计合作学者相似作者
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Bernice Woon Li Lee, You Heng Chuah,Jeehyun Yoon,Oleg V Grinchuk, Yajing Liang,Jayshree L Hirpara, Yating Shen,Loo Chien Wang,Yan Ting Lim,Tianyun Zhao,Radoslaw M Sobota,Tseng Tsai Yeo,
Cell death & diseaseno. 5 (2024): 338-338
Bernice Woon Li Lee, You Heng Chuah,Jeehyun Yoon,Oleg V. Grinchuk,Jia Feng, Yajing Liang,Jayshree L Hirpara, Ya Ting Shen,Loo Chien Wang,Yan Ting Lim,Tianyun Zhao,Radoslaw M Sobota,
Alan Prem Kumar, Ai Li Quake, Michelle Ker Xing Chang, Ting Zhou, Kelly Swee Ying Lim,Rajeev Singh, Robert Edwin Hewitt,Manuel Salto-Tellez,Shazib Pervaiz,Marie-Véronique Clément
crossref(2023)
npj Breast Cancerno. 1 (2023): 1-14
Alan Prem Kumar,Ai Li Quake,Michelle Ker Xing Chang, Ting Zhou, Kelly Swee Ying Lim,Rajeev Singh, Robert Edwin Hewitt,Manuel Salto-Tellez,Shazib Pervaiz,Marie-Véronique Clément
crossref(2023)
Yi Fei Lee,Leilei Chen,Valerie Chew,Edward Kai-Hua Chow,Lih-Wen Deng, Walter Hunziker,Ann Siew Gek Lee, Geraldine Leong,Joanne Ngeow,Shazib Pervaiz,Kanaga Sabapathy,Anders J. Skanderup,
Biologyno. 5 (2023): 647-647
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