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个人简介
The Perry Frey Group was formed in January 1969, when Perry started his own research group as an Assistant Professor of Chemistry at Ohio State University. The group moved to the Department of Biochemistry at the University of Wisconsin-Madison in 1981. In line with his interest in the mechanisms of action of enzymes, Perry chose for his first research subjects UDP-galactose 4-epimerase and the pyruvate dehydrogenase complex. The group grew with the addition of two or three graduate students each year. Within a few years, postdoctoral associates began joining the group, and other research projects were also introduced. Perry chose research projects that offered opportunities to discover new mechanisms in the actions of enzymes. The Frey group has focused efforts in several areas, including: Nicotinamide coenzyme-dependent nucleotide sugar modifying enzymes, mechanisms and structures of α-ketoacid dehydrogenase complexes, mechanisms of action of members of the histidine triad (HIT) family of enzymes, mechanisms of enzymatic and nonenzymatic phosphotransfer, free radical mechanisms in enzymology, and the characterization and role of a low-barrier (or short-strong) hydrogen bond in the action of chymotrypsin.
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