基本信息
浏览量:77
职业迁徙
个人简介
I am fascinated by how a collection of various chemical components in a cell can produce biological life under the constraints of physical laws. This is why I am a physiologist.
Research in my lab is driven by an interest in how biological processes are affected by chemical acidity. All tissues are exquisitely sensitive to changes in acidity (often expressed on a pH scale), therefore the remit of our research is broad. However, our two main pillars relate to the heart and to cancer. Acidity has a powerful effect on cardiac biology and is particularly important in cardiac diseases. In tumours, acidity is a chemical signature that influences disease progression. By discovering the mechanisms of these pH-responses, we hope to deliver new insights that may lead to better diagnosis, management and treatment of cardiovascular diseases and cancer. Most of our work is supported by the European Research Council (ERC) and the British Heart Foundation (BHF).
I joined the Department in 2001 as a PhD student working on spatial pH control in the heart in Richard Vaughan-Jones’ lab. Between 2004 and 2008, my research work, split between DPAG and Ken Spitzer’s lab at the University of Utah, focused on how changes in pH influence calcium signalling, a key driver of cardiac physiology. In 2008, I was awarded a Royal Society University Research Fellowship (URF) to study spatio-temporal aspects of pH control in cancer, and how acidic pH affects cancer cell behaviour and disease progression. I received mentorship from Adrian Harris. In 2017, I was awarded an ERC Consolidator Award to expand my research in the area of acid-selection in colorectal cancer. In that year, I also began leading a BHF Programme on the role of acidity in hypertrophic cardiac growth, which often precedes heart failure.
Research in my lab is driven by an interest in how biological processes are affected by chemical acidity. All tissues are exquisitely sensitive to changes in acidity (often expressed on a pH scale), therefore the remit of our research is broad. However, our two main pillars relate to the heart and to cancer. Acidity has a powerful effect on cardiac biology and is particularly important in cardiac diseases. In tumours, acidity is a chemical signature that influences disease progression. By discovering the mechanisms of these pH-responses, we hope to deliver new insights that may lead to better diagnosis, management and treatment of cardiovascular diseases and cancer. Most of our work is supported by the European Research Council (ERC) and the British Heart Foundation (BHF).
I joined the Department in 2001 as a PhD student working on spatial pH control in the heart in Richard Vaughan-Jones’ lab. Between 2004 and 2008, my research work, split between DPAG and Ken Spitzer’s lab at the University of Utah, focused on how changes in pH influence calcium signalling, a key driver of cardiac physiology. In 2008, I was awarded a Royal Society University Research Fellowship (URF) to study spatio-temporal aspects of pH control in cancer, and how acidic pH affects cancer cell behaviour and disease progression. I received mentorship from Adrian Harris. In 2017, I was awarded an ERC Consolidator Award to expand my research in the area of acid-selection in colorectal cancer. In that year, I also began leading a BHF Programme on the role of acidity in hypertrophic cardiac growth, which often precedes heart failure.
研究兴趣
论文共 107 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Cell Reportsno. 1 (2024): 113612-113612
CELL REPORTSno. 1 (2024)
Kyung Chan Park, Nicholas T. Crump, Niamh Louwman, Steve Krywawych, Yuen Jian Cheong, Iolanda Vendrell, Eleanor K. Gill,Mala Gunadasa-Rohling, Kerrie L. Ford,David Hauton, Marjorie Fournier,Elisabete Pires,
Nature Cardiovascular Researchno. 12 (2023): 1-25
Alan McIntyre,Alzbeta Hulikova,Ioanna Ledaki,Cameron Snell,Dean Singleton, Graham Steers, Peter Seden,Dylan Jones,Esther Bridges,Simon Wigfield,Ji-Liang Li,Angela Russell,
crossref(2023)
Richard Dumbill,Julija Rabcuka,John Fallon,Simon Knight,James Hunter,Daniel Voyce, Jacob Barrett, Matt Ellen,Annemarie Weissenbacher,Tetuko Kurniawan,Slawomir Blonski,Piotr Korczyk,
Bloodno. 8 (2023): 721-733
medRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
NATURE CARDIOVASCULAR RESEARCHno. 12 (2023): 1125-1126
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn