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Scientific activity of Paweł Kafarski was concentrated on elaboration of synthetic procedures suitable to produce phosphonate inhibitors (most likely in enantiomerically pure forms) of physiologically important enzymes, to mention only: aminopeptidases (targets for anti-cancer and anti-malarial drugs), cathepsin C (potential anti-tumor agents), glutamine synthetase (target for ant-tuberculosis agents), urease (antibacterials for treatment of stomach ulcer and stone formation in urinary tract) or L-phenylalanine ammonia lyase (potential herbicides). The design of ligands for these targets relied on knowledge of molecular mechanisms of the catalyzed reactions and on three-dimensional structures of the chosen proteins. He coauthored over 300 papers, which are well cited in the literature (over 6000 independent citations).
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crossref(2024)
Pharmaceuticals (Basel, Switzerland)no. 8 (2023): 1058-1058
Michał Paweł Jewgiński,Maciej Makowski,Małgorzata Pawełczak,Waldemar Goldeman, Alicja Trojanowska-Laskowska,Paweł Kafarski,Rafał Latajka
CHEMISTRY & BIODIVERSITYno. 5 (2022)
Frontiers in Chemistry (2022)
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