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Supported by academic funding from the EU and from Ireland, she has developed strategies for changing glycans into clinical markers in the diagnosis and treatment of cancers. An invited review of her published findings on glycans as biomarkers, co-authored with Barbara Adamczyk and Tharmala Tharmalingam, was recently published by the scientific journal Biochimica et Biophysica Acta. This research may one day lead to the development of simple blood tests to diagnose cancers and measure the impact of treatments.
In a collaboration with Waters, Prof. Rudd's research team at NIBRT also developed GlycoBase 3+, the world’s first database for glycan analysis by UltraPerformance Liquid Chromatography® (UPLC®). A repository of chromatographic retention positions expressed in glucose units for sets of glycan structures associated with a range of biotherapeutics, the GlycoBase 3+ Database gives biopharmaceutical manufacturers a fast and powerful tool for confirming the structure of various glycosylated proteins. When used during the manufacturing process, GlycoBase 3+ enables biopharmaceutical manufacturers to gain greater control over their manufacturing process, thereby ensuring safety, efficacy and regulatory compliance. NIBRT and Waters are co-marketing the database worldwide.
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Ashwini Maratha,Henning Stockmann, Karen P Coss,M Estela Rubio-Gozalbo,Ina Knerr,Maria Fitzgibbon,Terri P McVeigh, Patricia Foley, Catherine Moss, Hugh-Owen Colhoun,Britt van Erven, Kelly Stephens,
mag(2015)
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