Paula M Chilton - Institute for Cellular Therapeutics;Department of Microbiology and Immunology;University of Louisville;Institute for Cellular Therapeutics, University of Louisville

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Bio

Currently studies low-toxicity adjuvants for their ability to promote specific immune responses in low-inflammatory conditions. With her work is currently focused on vaccine adjuvants, the use of naturally-occurring forms of immune stimulatory molecules to counter inflammatory conditions is of keen interest and is directly applicable to attenuating immune responses after infection, trauma or stress-related insult.

Research Interests

Papers共 121 篇Author StatisticsCo-AuthorSimilar Experts

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Reduced White Matter Damage and Lower Neuroinflammatory Potential of Microglia and Macrophages in Hri/Eif2ak1-/- Mice after Contusive Spinal Cord Injury

Sujata Saraswat Ohri,Scott A. Myers,Benjamin Rood,Brandon L. Brown,Paula M. Chilton,Lukasz Slomnicki, Yu Liu,George Z. Wei,Kariena R. Andres, Divya Mohan,Russell M. Howard,Scott R. Whittemore,Michal Hetman

GLIA (2025)

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Impact of Chronic Ethanol Consumption and SARS-COV-2 on the Liver and Intestine: A Pilot Dose-Response Study in Mice

Smita Ghare,Dennis Warner,Jeffrey Warner,Paula M. Chilton,Jiyeon Lee,Jingwen Zhang, Min Wang,Josiah Hardesty, Rui Treves,Jon Gabbard, Charles Anderson,Lalit Batra, Chithra Sreenivasan, Jennifer Kraenzle, Matthew Mcculley, Stephanie Mccoy,Lihua Zhang,Wenke Feng,Dibson Dibe Gondim,Shirish Barve, Jian Zheng, Kenneth Palmer,Craig Mcclain,Irina Kirpich

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2025)

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Age-associated Temporal Decline in Butyrate-Producing Bacteria Plays a Key Pathogenic Role in the Onset and Progression of Neuropathology and Memory Deficits in 3×Tg-Ad Mice

Paula M. Chilton,Smita S. Ghare, Benjamin T. Charpentier,Scott A. Myers, Aakarsha V. Rao,Joseph F. Petrosino,Kristi L. Hoffman, John C. Greenwell,Neetu Tyagi,Jyotirmaya Behera, Yali Wang,Lucy J. Sloan,JingWen Zhang,Christopher B. Shields,Gregory E. Cooper,Leila Gobejishvili,Scott R. Whittemore,Craig J. McClain,Shirish S. Barve

Gut Microbesno. 1 (2024)

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ENDOGENOUS ENRICHMENT IN OMEGA 3 FATTY ACIDS ATTENUATED LIVER INJURY CAUSED BY CHRONIC ETHANOL CONSUMPTION AND SARS-COV-2 INFECTION IN MICE

Dennis Warner,Josiah Hardesty,Smita Ghare,Paula M. Chilton,Jiyeon Lee, Jingwen Zhang, Lihua Zhang,Min Wang,Jon Gabbard,Charles Anderson,Lalit Batra, Chithra Sreenivasan, Jennifer Kraenzle, Matthew McCulley, Stephanie Mccoy,Shirish Barve,Wenke Feng, Jian Zheng,Kenneth Palmer, Craig J. McClain,Irina A. Kirpich

GASTROENTEROLOGYno. 5 (2024): S1683-S1683

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Cognitive Impairment and Mortality after Hospitalization for Community-Acquired Pneumonia

Julio A Ramirez,Stephen Furmanek,Thomas R Chandler,William Mattingly,Anupama Raghuram,Ashley M Wilde,Smita S Ghare,Paula M Chilton,Shirish S Barve

Norton Healthcare Medical Journal (2024)

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Mo1536 ENDOGENOUS ENRICHMENT IN OMEGA 3 FATTY ACIDS ATTENUATED LIVER INJURY CAUSED BY CHRONIC ETHANOL CONSUMPTION AND SARS-COV-2 INFECTION IN MICE

Dennis Warner,Josiah Hardesty,Smita Ghare,Paula M. Chilton,Jiyeon Lee,Jingwen Zhang, Lihua Zhang, Min Wang,Jon Gabbard,Charles Anderson,Lalit Batra, Chithra Sreenivasan, Jennifer Kraenzle, Matthew McCulley, Stephanie McCoy,Shirish Barve,Wenke Feng, Jian Zheng,Kenneth Palmer,Craig J. McClain

Gastroenterologyno. 5 (2024): S-1683

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Effects of Chronic Binge Alcohol Consumption on Alzheimer’s Disease Neuropathogenesis in 3xtg‐ad Mice

Lucy J. Sloan,Paula M. Chilton, Aakarsha V. Rao, JingWen Zhang,Scott A. Myers,Sreelatha Reddy,Jiyeon Lee,Walter Rodriguez,Leila Gobejishvili,Julia Chariker,Eric Rouchka,Smita S. Ghare, Craig J. McClain,Shirish Barve

Alzheimer's &amp Dementia（2024）

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Transplantation of dysbiotic fecal microflora from alcohol-associated-hepatitis (aah) patients, leads to mallory-denk body formation and pathogenesis of alcoholic hepatitis in a mouse model

Smita Ghare,Paula Chilton,Manicka Vadhanam,Ben Charpentier,Richa Singhal,Scott Myers,John Greenwell,Jingwen Zhang,Mary Proctor,Leila Gobejishvili,Swati Joshi-Barve,Craig J. McClain,Shirish Barve

HEPATOLOGY (2023): S1666-S1666

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Oral Tributyrin Supplementation Attenuates Alzheimer’s Disease‐associated Neuropathology and Prevents Cognitive and Behavioral Deficits in the 3xtg‐ad Mouse Model

Paula M. Chilton,Smita S. Ghare, Benjamin T Charpentier,Scott A. Myers, Aakarsha V. Rao, J Caleb Greenwell,Neetu Tyagi,Jyotirmaya Behera,Yali Wang,Lucy J Sloan,JingWen Zhang,Leila Gobejishvili,Scott R Whittemore,Christopher B Shields, Gregory Cooper, Craig J. McClain,Shirish Barve

Alzheimer's &amp Dementiano. S13 (2023)

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Effects of binge alcohol on Alzheimer's disease pathogenesis in 3xTg-AD mice

L. J. Sloan,P. M. Chilton,Y. Wang,S. Reddy,J. W. Zhang,M. Wang,B. T. Charpentier,S. A. Myers,S. R. Whittemore,W. E. Rodriguez,L. Gobejishvili,S. S. Ghare,C. J. McClain,S. S. Barve

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2023): 389-389

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