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职业迁徙
个人简介
My research into viral replication employs molecular and structural biology and protein chemistry. My expertise includes the immunopathology of medically important viral infections including Ebola. Understanding the process of viral replication is essential for the development of improved diagnostics, vaccines and anti-viral therapeutic control strategies. Current studies are focused on three different viruses; dengue virus, a serious mosquito-borne disease in many tropical countries, Respiratory Syncytial Virus (RSV), a major cause of hospitalization of children with respiratory infections and KoRV, a retrovirus of koalas which we have shown is currently invading the koala germline and is linked with high rates of cancer in this iconic species.
Ongoing projects involve:
structural and molecular biology based studies on the dengue and West Nile virus proteins, NS3 (the viral protease) and E (a virus surface protein involved in cell binding and entry) and the RSV protein F (the viral fusion protein) as targets for antiviral drug design
sub-unit and DNA based vaccines for the engue viruses and respiratory syncytial virus
developing recombinant protein based platforms for improving viral diagnostics
elucidation of the spread and impact of KoRV in the Australian koala population
the role of selected retroviral proteins in immune-suppression.
Ongoing projects involve:
structural and molecular biology based studies on the dengue and West Nile virus proteins, NS3 (the viral protease) and E (a virus surface protein involved in cell binding and entry) and the RSV protein F (the viral fusion protein) as targets for antiviral drug design
sub-unit and DNA based vaccines for the engue viruses and respiratory syncytial virus
developing recombinant protein based platforms for improving viral diagnostics
elucidation of the spread and impact of KoRV in the Australian koala population
the role of selected retroviral proteins in immune-suppression.
研究兴趣
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medRxiv (2020)
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERYno. 2.0 (2019): A17-A18
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semanticscholar(2018)
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